H-Bond donorsPSA1532551406075Which of the following compounds is more likely to be a substrate for Pgp:CompoundH-Bond acceptorsMW IonizationA350pKa=3B520pKa=9CD400pKa=4D470pKa=84038

Compound AExplanation:Of the four compounds listed, compound A is most likely to be a substrate for…

Answered: H-Bond donors PSA 1532 55 140 60 75…

Biochemistry

9th Edition

ISBN:9781319114671

Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Chapter1: Biochemistry: An Evolving Science

Section: Chapter Questions

Problem 1P

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The catalytic triad consists of Asp, His, and Ser. What would be an alternative for histidine and how would we draw the interactions in a mechanism?
What kind of catalysis is cysteine driving in this picture? S Los i fy R……—NHR N-H---S O. N-H H-N H-N. O Metal catalysis Covalent catalysis Base catalysis O Acid catalysis NHR²
Consider the positively charged amino acid lysine Lys2+ 21 COOH I H&N-C-H I pH 14 12 10 8 6 4 2 0 CH₂ I CH₂ I CH₂ I CH₂ T NH₂+ 0 Nelson p85 2.18 = 2.18 PK₁ Lys+ COO™ I H₂N-C-H H₂N-C-H ī I -----) 8.95 Lysº 8.95 pK₂ pka carboxyl = 2.19 pkaamino = 9.67 pka sidechain = 4.25 COO™ I CH₂ I CH₂ I CH₂ I CH₂ I NH₂¹ 1.0 2.0 Equivalents of OH added- COO™ I H₂N-C-H I 10.79 1 10.79 pk Isoelectric point Lys CH₂2 I CH₂ I CH₂ I CH₂ T NH₂ 3.0 +H3N NH3+ T CH₂ T CH₂ CH₂ CH₂ -COO™ H Lysine (Lys, K) Physiological pH = 7.4 < pl → Amino acid is positively charged at physiological pH 1. Consider glutamate in its fully protonated form (e.g. in a pH = 1 solution) 1) Draw all the forms of glutamate at various pH 2) Calculate the pl of this amino acid 3) Sketch a titration curve showing pH as a function of added [OH-] and locate the predominant forms of histidine in the curve STEPS: 1. Find the H atoms that can be removed on the molecule 2. Associated a pka value to each removable H. 3. Draw the Aa structure at:…
E* S P₁₁ P₂ E E-S₁ E-S₁-S₂ E-P₁-P₂ E*-P₂ E* Which of these 2 options represents a Sequential Ordered bisubstrate reaction? (label the other reaction as well) P₁ P₂ E-S₁-S₂ E-P₁-P₂ E-P₂ E is E E-S₁ S E◄
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H-Bond donors PSA 1532 55 140 60 75 Which of the following compounds is more likely to be a substrate for Pgp: Compound H-Bond acceptors MW Ionization A 350 pKa=3 B 520 pKa=9 CD 400 pKa=4 D 470 pKa=8 4038