What is the significance of the blue regions of the following molecule?MeMe Me HoppoMesteroidskeletonOMeMeNone of the answersO They are prone to metabolism, thus limiting the lifetime of the drugO They introduce a dipole moment to the molecule allowing the correct alignment of binding groups when the molecule binds tothe binding siteO They represent the skeleton of acetylcholineO They are polar groups that increase water solubility

The molecule in question is pancuronium. Pancuronium is a drug that is used to competitively inhibit…

Answered: What is the significance of the blue…

Biochemistry

9th Edition

ISBN:9781319114671

Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Chapter1: Biochemistry: An Evolving Science

Section: Chapter Questions

Problem 1P

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3. Solve the sequence of an oligopeptide 7 residues long which gave: Asp Leu Lys Met Phe Tyr The following facts were observed: a. Trypsin treatment had no apparent effect b. The PTH derivative from Edman degradation was c. Brief chymotrypsin treatment yielded several products including but not limited to a dipeptide and a tetrapeptide. The amino acid composition of the tetrapeptide was Leu, Lys, and Met. d. Cyanogen bromide treatment yielded a dipeptide, a tetrapeptide, and a free Lys. Instructions Make use of the table below to determine the sequence of the mystery protein.
Prepare a schematic diagram and present it as though it were a Figure in a publication (scientific journal or textbook) The diagram should illustrate the interactions made between the key components of (a) total and (b) non-specific binding reactions. In preparing your diagram，you should reflect on the role of each of the components of the reaction mixtures, and why the subtraction of non-specific from total binding allows us to calculate specific binding. The diagram Legend should be brief but informative.
Consider the following dipeptides: AC HE TG LR VK How many of the dipeptides in this group that would stick to an anion exchange column at pH-8? Please give me the whole number as the answer, 0, 1, 2 etc Amino Acid pKac pKaN pKaR 9.8 9.9 97 2.4 Glycine Alanine 23 Valios 222
Is there anyway to draw a visual diagram for this as the explanation does not make sense how can 2 aspartates interact with each other under physiological pH?
3. Solve the sequence of an oligopeptide 7 residues long which gave: Asp Leu Lys Met Phe Tyr The following facts were observed: a. Trypsin treatment had no apparent effect b. The PTH derivative from Edman degradation was c. Brief chymotrypsin treatment yielded several products including but not limited to a dipeptide and a tetrapeptide. The amino acid composition of the tetrapeptide was Leu, Lys, and Met. d. Cyanogen bromide treatment yielded a dipeptide, a tetrapeptide, and a free Lys.
Explain this quesiton in descrition format whether non-barbiturate drug classes are labeled at a lower or higher selection compared to barbiturates?
1.Substituents exhibit strong steric repulsion at the GABAA receptor ？what does it means？？ 2. Substitutions at C-6, C-8, and C-9 lower the activity？where is C-6, C-8, and C-9 ？can anyone help to lable out？
A company has formulated their drug into a salt using the reaction below. A medical student would like to know possible reasons for making this salt. You explain that the new salt could have been made into different products to: (SELECT ALL THAT APPLY) HO Drug X Currently Selected: A, B - A improve oral palatability (improve taste). B formulate an IV injection, C make a long acting IM depot injection D make a lipid soluble supsension for pediatric formulation S O
The aromatic side chain of Trp residues in proteins and peptides can be chemically modified by two photochemical reactions using ultraviolet light (hv) at 20°C (Figure 1). hv CCI3CO₂H (10 mm), Buffer A (pH 8.0) O HO HN HN- O A. Acidic NH ww O B. Basic O c. Hydrophobic O D. Polar neutral OB. Indole NH ww Figure 1 Photochemical reactions of Trp side chain with CHCl3 and CCI₂CO₂H O A. Imidazole Each substitution on Trp replaces one hydrogen atom attached to a carbon somewhere on the indole ring. Photochemical modification percentages of various Trp residues in carbonic anhydrase at 20°C are shown in Table 1. Table 1 Photochemically Modified in Carbonic Anhydrase Reactant Buffer W4 W15 W96 W122 W190 W207 W243 51% 0% 44% A 37% 0% 0% CHCI 3 0% CHCI₂ B 0% 0% 0% 0% 0% 0% 55% CCI,CO₂H A 72% 66% 0% 100% 100% 0% 75% O c. Pyrimidine OD. Pyrrole hv W15 and W96, which are in the interior of carbonic anhydrase, are 21% and 29% modified respectively by 10 mM CHCl3 in Buffer A at 75°C, a temperature…
The following structures were introduced as neuromuscular blocking agents. Structure B is derived from structure A. What was the main reason for incorporating additional ester groups? O To enhance hydrogen bonding interactions with the binding site. O To increase the polarity of the drug. O To decrease the stability of the drug O To alter the conformation of the molecule.
The amylopectin molecule differs from the glyco- gen molecule by: |A The nature of their monosaccharides; B The nature of the osidic bond of the main chain; C Their number of reducing extremities; D The length of their ramifications; E The nature of the osidic bond established between their ramifications and their main chain.
Tetrodotoxin identify the species which releases the toxin (if it is man-made then this will be all that is required for this part) identify the step disrupted in the neuromuscular junction pathway Provide any consequences of this disruption. Does the toxin have any applications in biomedicine as a painkiller, disease treatment or analgesic? Provide your source in APA format for each. If this is missing no credit will be awarded.

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