Substituting antisense oligonucleotide non-bridging oxygen atoms with a sulpha atom: Select

Biochemistry
9th Edition
ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Chapter1: Biochemistry: An Evolving Science
Section: Chapter Questions
Problem 1P
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-f
ion
Substituting antisense oligonucleotide non-bridging oxygen atoms with a sulpha atom:
Select one:
O a. Decreases oligonucleotide stability in biological fluids
O b. Increases oligonucleotide hydrophobicity increasing the likelihood of it partitioning a
O c.
None of these
Od.
Increases oligonucleotide stability in biological fluids
Oe. Has no effect on oligonucleotide stability in biological fluids
Therapeutic replacement genes need to be delivered to which intracellular compartment?
Select one:
O a. The chloroplast
O b. The lysosome
The Nucleus
O c.
O d. The ribosome
O e.
The Golgi
Give both answer only with little bit
explanation
Asap
Thanks
Transcribed Image Text:on -f ion Substituting antisense oligonucleotide non-bridging oxygen atoms with a sulpha atom: Select one: O a. Decreases oligonucleotide stability in biological fluids O b. Increases oligonucleotide hydrophobicity increasing the likelihood of it partitioning a O c. None of these Od. Increases oligonucleotide stability in biological fluids Oe. Has no effect on oligonucleotide stability in biological fluids Therapeutic replacement genes need to be delivered to which intracellular compartment? Select one: O a. The chloroplast O b. The lysosome The Nucleus O c. O d. The ribosome O e. The Golgi Give both answer only with little bit explanation Asap Thanks
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