What drug design strategy has been used here?

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In the design of H2 antagonists, the polar guanidine group of compound A was proposed to interact
with the antagonist binding region by two hydrogen bonds. This compelled researchers to derivatize
compound B from compound A.
HN
EN
Chain Extension
Rigidification
ZI
compound A
What drug design strategy has been used here?
Simplification
H₂N
NH
Substituent variation
HN
NH₂
HN NH
N
compound B
Transcribed Image Text:In the design of H2 antagonists, the polar guanidine group of compound A was proposed to interact with the antagonist binding region by two hydrogen bonds. This compelled researchers to derivatize compound B from compound A. HN EN Chain Extension Rigidification ZI compound A What drug design strategy has been used here? Simplification H₂N NH Substituent variation HN NH₂ HN NH N compound B
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