A small-scale pedigree study involving 15 families with a total of 50 children was performed to determine whether a SNP in a candidate gene is linked to a disease. The result showed that among 22 children who developed the disease, 19 belonged to non-recombinants while 3 recombinants. For the remaining 28 children, 21 were non-recombinants and 7 belonged to recombinants. A Lod (Z) score can be calculated and used to determine whether this SNP is linked to the disease. By using a very stringent threshold, which of the following conclusions is correct? OA.Z is approximately 4.03, indicating a linkage O B. Z=0.25, indicating no linkage OC.Z=0.2, indicating no linkage O D.Z is approximately 4.19, indicating a linkage
A small-scale pedigree study involving 15 families with a total of 50 children was performed to determine whether a SNP in a candidate gene is linked to a disease. The result showed that among 22 children who developed the disease, 19 belonged to non-recombinants while 3 recombinants. For the remaining 28 children, 21 were non-recombinants and 7 belonged to recombinants. A Lod (Z) score can be calculated and used to determine whether this SNP is linked to the disease. By using a very stringent threshold, which of the following conclusions is correct? OA.Z is approximately 4.03, indicating a linkage O B. Z=0.25, indicating no linkage OC.Z=0.2, indicating no linkage O D.Z is approximately 4.19, indicating a linkage
Human Anatomy & Physiology (11th Edition)
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ISBN:9780134580999
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![A small-scale pedigree study involving 15 families with a total of 50 children was performed to determine whether a SNP
in a candidate gene is linked to a disease. The result showed that among 22 children who developed the disease, 19
belonged to non-recombinants while 3 recombinants. For the remaining 28 children, 21 were non-recombinants and 7
belonged to recombinants. A Lod (Z) score can be calculated and used to determine whether this SNP is linked to the
disease. By using a very stringent threshold, which of the following conclusions is correct?
O A.Z is approximately 4.03, indicating a linkage
O B. Z=0.25, indicating no linkage
OCZ=0.2, indicating no linkage
O D.Z is approximately 4.19, indicating a linkage](/v2/_next/image?url=https%3A%2F%2Fcontent.bartleby.com%2Fqna-images%2Fquestion%2F47e03722-4d1a-4cbd-b64d-6ec4d7a9e7d1%2Ffc21392e-0ce5-400c-adf3-78bd39f856a5%2Fbv677in_processed.jpeg&w=3840&q=75)
Transcribed Image Text:A small-scale pedigree study involving 15 families with a total of 50 children was performed to determine whether a SNP
in a candidate gene is linked to a disease. The result showed that among 22 children who developed the disease, 19
belonged to non-recombinants while 3 recombinants. For the remaining 28 children, 21 were non-recombinants and 7
belonged to recombinants. A Lod (Z) score can be calculated and used to determine whether this SNP is linked to the
disease. By using a very stringent threshold, which of the following conclusions is correct?
O A.Z is approximately 4.03, indicating a linkage
O B. Z=0.25, indicating no linkage
OCZ=0.2, indicating no linkage
O D.Z is approximately 4.19, indicating a linkage
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