a. What is the mode of transmission of this disease? b. Which SNP allele (ASO1 or ASO2) is originally linked to the disease gene? c. Draw a diagram of the event that gave rise to the genotype of individual IV-5.

Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
Section: Chapter Questions
Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...
icon
Related questions
Topic Video
Question
Below is a pedigree showing transmission of a disease; affected individuals are
indicated by solid circles or boxes. Represented below the pedigree are two nylon membranes; DNA
samples from each individual in the pedigree were spotted in identical fashion on each membrane. Each
individual's DNA appears directly below his or her position in the pedigree. Each membrane was
hybridized with allele specific oligonucleotides that detect the two alternative alleles of a single SNP locus
(ASO 1 and ASO 2). Positive hybridization is represented as a filled circle and lack of hybridization is
represented as an open circle.
I
11
III
IV
V
ASO 1
ASO 2
To
1 2 3 4 5 6
a. What is the mode of transmission of this disease?
12
b. Which SNP allele (ASO1 or ASO2) is originally linked to the disease gene?
c. Draw a diagram of the event that gave rise to the genotype of individual IV-5.
d. Individual V-1 is an unborn fetus. If the SNP locus is 10 CM from the disease locus, what is the
likelihood that he will express the disease phenotype? Show your work.
Transcribed Image Text:Below is a pedigree showing transmission of a disease; affected individuals are indicated by solid circles or boxes. Represented below the pedigree are two nylon membranes; DNA samples from each individual in the pedigree were spotted in identical fashion on each membrane. Each individual's DNA appears directly below his or her position in the pedigree. Each membrane was hybridized with allele specific oligonucleotides that detect the two alternative alleles of a single SNP locus (ASO 1 and ASO 2). Positive hybridization is represented as a filled circle and lack of hybridization is represented as an open circle. I 11 III IV V ASO 1 ASO 2 To 1 2 3 4 5 6 a. What is the mode of transmission of this disease? 12 b. Which SNP allele (ASO1 or ASO2) is originally linked to the disease gene? c. Draw a diagram of the event that gave rise to the genotype of individual IV-5. d. Individual V-1 is an unborn fetus. If the SNP locus is 10 CM from the disease locus, what is the likelihood that he will express the disease phenotype? Show your work.
Expert Solution
steps

Step by step

Solved in 2 steps

Blurred answer
Knowledge Booster
Mitochondrial mutations
Learn more about
Need a deep-dive on the concept behind this application? Look no further. Learn more about this topic, biology and related others by exploring similar questions and additional content below.
Similar questions
Recommended textbooks for you
Human Anatomy & Physiology (11th Edition)
Human Anatomy & Physiology (11th Edition)
Biology
ISBN:
9780134580999
Author:
Elaine N. Marieb, Katja N. Hoehn
Publisher:
PEARSON
Biology 2e
Biology 2e
Biology
ISBN:
9781947172517
Author:
Matthew Douglas, Jung Choi, Mary Ann Clark
Publisher:
OpenStax
Anatomy & Physiology
Anatomy & Physiology
Biology
ISBN:
9781259398629
Author:
McKinley, Michael P., O'loughlin, Valerie Dean, Bidle, Theresa Stouter
Publisher:
Mcgraw Hill Education,
Molecular Biology of the Cell (Sixth Edition)
Molecular Biology of the Cell (Sixth Edition)
Biology
ISBN:
9780815344322
Author:
Bruce Alberts, Alexander D. Johnson, Julian Lewis, David Morgan, Martin Raff, Keith Roberts, Peter Walter
Publisher:
W. W. Norton & Company
Laboratory Manual For Human Anatomy & Physiology
Laboratory Manual For Human Anatomy & Physiology
Biology
ISBN:
9781260159363
Author:
Martin, Terry R., Prentice-craver, Cynthia
Publisher:
McGraw-Hill Publishing Co.
Inquiry Into Life (16th Edition)
Inquiry Into Life (16th Edition)
Biology
ISBN:
9781260231700
Author:
Sylvia S. Mader, Michael Windelspecht
Publisher:
McGraw Hill Education