a. What is the mode of transmission of this disease? b. Which SNP allele (ASO1 or ASO2) is originally linked to the disease gene? c. Draw a diagram of the event that gave rise to the genotype of individual IV-5.
a. What is the mode of transmission of this disease? b. Which SNP allele (ASO1 or ASO2) is originally linked to the disease gene? c. Draw a diagram of the event that gave rise to the genotype of individual IV-5.
Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
Section: Chapter Questions
Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...
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Transcribed Image Text:Below is a pedigree showing transmission of a disease; affected individuals are
indicated by solid circles or boxes. Represented below the pedigree are two nylon membranes; DNA
samples from each individual in the pedigree were spotted in identical fashion on each membrane. Each
individual's DNA appears directly below his or her position in the pedigree. Each membrane was
hybridized with allele specific oligonucleotides that detect the two alternative alleles of a single SNP locus
(ASO 1 and ASO 2). Positive hybridization is represented as a filled circle and lack of hybridization is
represented as an open circle.
I
11
III
IV
V
ASO 1
ASO 2
To
1 2 3 4 5 6
a. What is the mode of transmission of this disease?
12
b. Which SNP allele (ASO1 or ASO2) is originally linked to the disease gene?
c. Draw a diagram of the event that gave rise to the genotype of individual IV-5.
d. Individual V-1 is an unborn fetus. If the SNP locus is 10 CM from the disease locus, what is the
likelihood that he will express the disease phenotype? Show your work.
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