FBBS 2 Worksheet 2NameHINT: when you are explaining mechanisms affected by mutations, think about molecular interactions, orenzymatic functions, or conformational changes that are involved in the normal pathways, since these are theaspects most likely to be affected by mutations or drugs, or viral proteins.If a consequence of a mutation/drug/virus results in a cdk being more frequently active, then the cell cycle willproceed at the given checkpoint. If the consequence of a mutation/drug/virus results in a cdk beinginactivated or inhibited, then the cell cycle is stopped at the given checkpoint.cdc2kinaseInactive1) Given the following diagram of a mechanism regulating the cell cycle of the fission yeast S. pombe.Interphase (G₂)CAKWee1CyclinThr161-P Tyr15-Pcdc2kinaseCyclinInactiveThr161-Pcdc25G₂ fissionyeast cellcdc2kinaseCyclinActiveInterphase (G₁)Post-mitoticfissionyeast cellsDatecdc2kinaseDr. MilaniInactiveCyclinDegradationA) Predict the consequences on the cell cycle if the amino acid tyrosine15 of cdc2 was mutated to an alanine,which cannot be phosphorylated. And explain clearly the reason for this prediction. (just talk about the cellcycle, keep your description of a phenotype for part (B)B) Describe and explain the possible phenotype of the yeast strain carrying Tyrosine15 to alanine mutation incdc2, compared to wild type yeast. (use what you learn about S. pombe mutants in class)

Name: FBBS 2 Worksheet 2NameHINT: when you are explaining mechanisms affect
Uploaded: 2024-03-20T06:42:55.000Z
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Description: FBBS 2 Worksheet 2NameHINT: when you are explaining mechanisms affected by mutations, think about molecular interactions, orenzymatic functions, or conformational changes that are involved in the normal pathways, since these are theaspects most like