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6a. C. elegans display a very characteristic sinusoidal movement, like a snake slithering. Imagine you complete a genetic screen in C. elegans for immobile worms, that lack this ability to move. These sorts of mutants belong to a class of mutants called "unc" mutants, which stands for "uncoordinated." Unc mutants exhibit some degree of paralysis from minor to severe, and they are typically not lethal. Imagine you create a recessive mutation in the unc-1 gene, through a mutagenesis. You initially collect a heterozygote: unc-1(-)/+ ( unc-1(-) is the loss-of-function mutation and “+” represents the wild type allele at that gene). You allow the C.elegans mutant to self-fertilize. What percentage of the offspring would now be homozygous for the mutation? 6b. Say you've only been working with your unc-1(-) mutant at 26 degrees Celsius, the restrictive condition. What experiment would you do and what result would expect if the mutant you were dealing with was temperature-sensitive?

6a. C. elegans display a very characteristic sinusoidal movement, like a snake slithering. Imagine you complete a genetic screen in C. elegans for immobile worms, that lack this ability to move. These sorts of mutants belong to a class of mutants called "unc" mutants, which stands for "uncoordinated." Unc mutants exhibit some degree of paralysis from minor to severe, and they are typically not lethal. Imagine you create a recessive mutation in the unc-1 gene, through a mutagenesis. You initially collect a heterozygote: unc-1(-)/+ ( unc-1(-) is the loss-of-function mutation and “+” represents the wild type allele at that gene). You allow the C.elegans mutant to self-fertilize. What percentage of the offspring would now be homozygous for the mutation? 6b. Say you've only been working with your unc-1(-) mutant at 26 degrees Celsius, the restrictive condition. What experiment would you do and what result would expect if the mutant you were dealing with was temperature-sensitive?

Human Anatomy & Physiology (11th Edition)
Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
Section: Chapter Questions
Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...
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6a. C. elegans display a very characteristic sinusoidal movement, like a snake slithering. Imagine you complete a genetic screen in C. elegans for immobile worms, that lack this ability to move. These sorts of mutants belong to a class of mutants called "unc" mutants, which stands for "uncoordinated." Unc mutants exhibit some degree of paralysis from minor to severe, and they are typically not lethal. Imagine you create a recessive mutation in the unc-1 gene, through a mutagenesis. You initially collect a heterozygote: unc-1(-)/+ ( unc-1(-) is the loss-of-function mutation and “+” represents the wild type allele at that gene). You allow the C.elegans mutant to self-fertilize. What percentage of the offspring would now be homozygous for the mutation? 6b. Say you've only been working with your unc-1(-) mutant at 26 degrees Celsius, the restrictive condition. What experiment would you do and what result would expect if the mutant you were dealing with was temperature-sensitive?
Transcribed Image Text:6a. C. elegans display a very characteristic sinusoidal movement, like a snake slithering. Imagine you complete a genetic screen in C. elegans for immobile worms, that lack this ability to move. These sorts of mutants belong to a class of mutants called "unc" mutants, which stands for "uncoordinated." Unc mutants exhibit some degree of paralysis from minor to severe, and they are typically not lethal. Imagine you create a recessive mutation in the unc-1 gene, through a mutagenesis. You initially collect a heterozygote: unc-1(-)/+ ( unc-1(-) is the loss-of-function mutation and “+” represents the wild type allele at that gene). You allow the C.elegans mutant to self-fertilize. What percentage of the offspring would now be homozygous for the mutation? 6b. Say you've only been working with your unc-1(-) mutant at 26 degrees Celsius, the restrictive condition. What experiment would you do and what result would expect if the mutant you were dealing with was temperature-sensitive?
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