A mutated form of the a subunit of the heterotrimeric G protein has been identified. It is found to readily exchange GDP for GTP even the absence of an activated receptor. a. What would be the effect on a signaling pathway containing the mutated protein? And in light of your answer would this protein more likely to function as an oncogene or as a tumor suppressor. Briefly explain your answer. b. A paper finds an interesting study where an analog of GTP (GTPYS, guanosine 5'-0-[gamma-thio]triphosphate) is used to alter G-protein to activity. The authors claim that the data below suggest that it could perhaps be used as a treatment for patients with the mutated a subunit as described above. What do you think? [PJ GTPYS Rate of Hydrolysis Hill GTP III GTPYS Time
A mutated form of the a subunit of the heterotrimeric G protein has been identified. It is found to readily exchange GDP for GTP even the absence of an activated receptor. a. What would be the effect on a signaling pathway containing the mutated protein? And in light of your answer would this protein more likely to function as an oncogene or as a tumor suppressor. Briefly explain your answer. b. A paper finds an interesting study where an analog of GTP (GTPYS, guanosine 5'-0-[gamma-thio]triphosphate) is used to alter G-protein to activity. The authors claim that the data below suggest that it could perhaps be used as a treatment for patients with the mutated a subunit as described above. What do you think? [PJ GTPYS Rate of Hydrolysis Hill GTP III GTPYS Time
Biochemistry
6th Edition
ISBN:9781305577206
Author:Reginald H. Garrett, Charles M. Grisham
Publisher:Reginald H. Garrett, Charles M. Grisham
Chapter32: The Reception And Transmission Of Extracellular Information
Section: Chapter Questions
Problem 21P
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