a) Draw reaction coordinate diagrams for binding of both compounds to the enzyme: Ka (nM) Kon (M's²) 5.8 x 106 Kofr (s) 4.3 x 103 Compound 0.8 Y 0.4 1.0 x 105 4.3 x 105 b) Explain the important differences between both graphs.

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Chapter1: Biochemistry: An Evolving Science
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a) Draw reaction coordinate diagrams for binding of both compounds to the enzyme:
Compound
Ka (nM) Kon (M-g?)
koff (s)
4.3 x 103
4.3 x 105
0.8
5.8 x 106
Y
0.4
1.0 x 105
b) Explain the important differences between both graphs.
Transcribed Image Text:a) Draw reaction coordinate diagrams for binding of both compounds to the enzyme: Compound Ka (nM) Kon (M-g?) koff (s) 4.3 x 103 4.3 x 105 0.8 5.8 x 106 Y 0.4 1.0 x 105 b) Explain the important differences between both graphs.
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