Dehalogenase enzymes catalyze the clevage of C-X bonds. One such dehalogenase catalyzes the following reaction. An active site aspartate is thought to carry out the initial nucleophilic attack that expels the chloride. Select the most likely intermediate in the reaction. (Note the stereochemistry. Refer to P11.19 in the textbook if needed.) O CO₂ K CO₂ kez ke ft kez ku -CH₂ N B O A B C H₂O Cr OE ÇO₂ HOTH CH₂ E CI CH₂

Biochemistry
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Chapter1: Biochemistry: An Evolving Science
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Dehalogenase enzymes catalyze the clevage of C-X bonds. One such dehalogenase catalyzes the
following reaction. An active site aspartate is thought to carry out the initial nucleophilic attack that
expels the chloride. Select the most likely intermediate in the reaction. (Note the stereochemistry.
Refer to P11.19 in the textbook if needed.)
O
O
A
C
D
OE
-CH₂
H
H₂C™ CO₂
H
B
CO₂
CI
N
H₂O Cr
CO₂
H
CO₂
нотум
CH3
D
CO₂
five
N
E
CH₂
Transcribed Image Text:Dehalogenase enzymes catalyze the clevage of C-X bonds. One such dehalogenase catalyzes the following reaction. An active site aspartate is thought to carry out the initial nucleophilic attack that expels the chloride. Select the most likely intermediate in the reaction. (Note the stereochemistry. Refer to P11.19 in the textbook if needed.) O O A C D OE -CH₂ H H₂C™ CO₂ H B CO₂ CI N H₂O Cr CO₂ H CO₂ нотум CH3 D CO₂ five N E CH₂
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