9. If you were to compare an agonist bound receptor and an antagonist bound receptor Which of the following statements is common to all receptors? a) A channel opens when activated b) There is a conformational change when activated c) The receptor is dimerized when activated d) There are no structural differences 10. Most xenobiotics act transiently and therefore interact with their receptor through weak interactions. Which type of interaction would you not expect to see when examining the receptor ligand interactions for an uncharacterized xenobiotic? a) Van der Waals interactions b) Hydrogen bonds c) Hydrophobic interactions d) All of the above e) None of the above 11. Name the interaction the arrow is pointing to (image to the right): a) Hydrogen Bond b) Pi stacking c) Cation-pi interaction d) Electrostatic interaction H-O 0 NH3 -H 12. Non-competitive antagonists share which of the following characteristics with non-competitive enzyme inhibitors? a) Bind covalently with target protein & permanently inhibit receptor activation or enzyme activity b) Bind reversibly with target protein & effects can be overcome by increasing agonist or substrate concentrations c) Bind irreversibly with target protein & effects can be overcome by increasing agonist or substrate concentrations d) Bind with target protein at allosteric site & inhibit receptor activation or enzyme activity e) Bind with target protein at orthosteric site & inhibit receptor activation or enzyme activity 4

Biology (MindTap Course List)
11th Edition
ISBN:9781337392938
Author:Eldra Solomon, Charles Martin, Diana W. Martin, Linda R. Berg
Publisher:Eldra Solomon, Charles Martin, Diana W. Martin, Linda R. Berg
Chapter6: Cell Communication
Section6.3: Reception
Problem 4LO
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9. If you were to compare an agonist bound receptor and an antagonist bound receptor Which of the
following statements is common to all receptors?
a) A channel opens when activated
b) There is a conformational change when activated
c) The receptor is dimerized when activated
d) There are no structural differences
10. Most xenobiotics act transiently and therefore interact with their receptor through weak interactions. Which
type of interaction would you not expect to see when examining the receptor ligand interactions for an
uncharacterized xenobiotic?
a) Van der Waals interactions
b) Hydrogen bonds
c) Hydrophobic interactions
d) All of the above
e) None of the above
11. Name the interaction the arrow is pointing to (image to the right):
a) Hydrogen Bond
b) Pi stacking
c) Cation-pi interaction
d) Electrostatic interaction
H-O
0
NH3
-H
12. Non-competitive antagonists share which of the following characteristics with non-competitive enzyme
inhibitors?
a) Bind covalently with target protein & permanently inhibit receptor activation or enzyme activity
b) Bind reversibly with target protein & effects can be overcome by increasing agonist or substrate
concentrations
c) Bind irreversibly with target protein & effects can be overcome by increasing agonist or substrate
concentrations
d) Bind with target protein at allosteric site & inhibit receptor activation or enzyme activity
e) Bind with target protein at orthosteric site & inhibit receptor activation or enzyme activity
4
Transcribed Image Text:9. If you were to compare an agonist bound receptor and an antagonist bound receptor Which of the following statements is common to all receptors? a) A channel opens when activated b) There is a conformational change when activated c) The receptor is dimerized when activated d) There are no structural differences 10. Most xenobiotics act transiently and therefore interact with their receptor through weak interactions. Which type of interaction would you not expect to see when examining the receptor ligand interactions for an uncharacterized xenobiotic? a) Van der Waals interactions b) Hydrogen bonds c) Hydrophobic interactions d) All of the above e) None of the above 11. Name the interaction the arrow is pointing to (image to the right): a) Hydrogen Bond b) Pi stacking c) Cation-pi interaction d) Electrostatic interaction H-O 0 NH3 -H 12. Non-competitive antagonists share which of the following characteristics with non-competitive enzyme inhibitors? a) Bind covalently with target protein & permanently inhibit receptor activation or enzyme activity b) Bind reversibly with target protein & effects can be overcome by increasing agonist or substrate concentrations c) Bind irreversibly with target protein & effects can be overcome by increasing agonist or substrate concentrations d) Bind with target protein at allosteric site & inhibit receptor activation or enzyme activity e) Bind with target protein at orthosteric site & inhibit receptor activation or enzyme activity 4
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