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9. If you were to compare an agonist bound receptor and an antagonist bound receptor Which of the following statements is common to all receptors? a) A channel opens when activated b) There is a conformational change when activated c) The receptor is dimerized when activated d) There are no structural differences 10. Most xenobiotics act transiently and therefore interact with their receptor through weak interactions. Which type of interaction would you not expect to see when examining the receptor ligand interactions for an uncharacterized xenobiotic? a) Van der Waals interactions b) Hydrogen bonds c) Hydrophobic interactions d) All of the above e) None of the above 11. Name the interaction the arrow is pointing to (image to the right): a) Hydrogen Bond b) Pi stacking c) Cation-pi interaction d) Electrostatic interaction H-O 0 NH3 -H 12. Non-competitive antagonists share which of the following characteristics with non-competitive enzyme inhibitors? a) Bind covalently with target protein & permanently inhibit receptor activation or enzyme activity b) Bind reversibly with target protein & effects can be overcome by increasing agonist or substrate concentrations c) Bind irreversibly with target protein & effects can be overcome by increasing agonist or substrate concentrations d) Bind with target protein at allosteric site & inhibit receptor activation or enzyme activity e) Bind with target protein at orthosteric site & inhibit receptor activation or enzyme activity 4

9. If you were to compare an agonist bound receptor and an antagonist bound receptor Which of the following statements is common to all receptors? a) A channel opens when activated b) There is a conformational change when activated c) The receptor is dimerized when activated d) There are no structural differences 10. Most xenobiotics act transiently and therefore interact with their receptor through weak interactions. Which type of interaction would you not expect to see when examining the receptor ligand interactions for an uncharacterized xenobiotic? a) Van der Waals interactions b) Hydrogen bonds c) Hydrophobic interactions d) All of the above e) None of the above 11. Name the interaction the arrow is pointing to (image to the right): a) Hydrogen Bond b) Pi stacking c) Cation-pi interaction d) Electrostatic interaction H-O 0 NH3 -H 12. Non-competitive antagonists share which of the following characteristics with non-competitive enzyme inhibitors? a) Bind covalently with target protein & permanently inhibit receptor activation or enzyme activity b) Bind reversibly with target protein & effects can be overcome by increasing agonist or substrate concentrations c) Bind irreversibly with target protein & effects can be overcome by increasing agonist or substrate concentrations d) Bind with target protein at allosteric site & inhibit receptor activation or enzyme activity e) Bind with target protein at orthosteric site & inhibit receptor activation or enzyme activity 4

Biochemistry
Biochemistry
9th Edition
ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Chapter1: Biochemistry: An Evolving Science
Section: Chapter Questions
Problem 1P
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9. If you were to compare an agonist bound receptor and an antagonist bound receptor Which of the following statements is common to all receptors? a) A channel opens when activated b) There is a conformational change when activated c) The receptor is dimerized when activated d) There are no structural differences 10. Most xenobiotics act transiently and therefore interact with their receptor through weak interactions. Which type of interaction would you not expect to see when examining the receptor ligand interactions for an uncharacterized xenobiotic? a) Van der Waals interactions b) Hydrogen bonds c) Hydrophobic interactions d) All of the above e) None of the above 11. Name the interaction the arrow is pointing to (image to the right): a) Hydrogen Bond b) Pi stacking c) Cation-pi interaction d) Electrostatic interaction H-O 0 NH3 -H 12. Non-competitive antagonists share which of the following characteristics with non-competitive enzyme inhibitors? a) Bind covalently with target protein & permanently inhibit receptor activation or enzyme activity b) Bind reversibly with target protein & effects can be overcome by increasing agonist or substrate concentrations c) Bind irreversibly with target protein & effects can be overcome by increasing agonist or substrate concentrations d) Bind with target protein at allosteric site & inhibit receptor activation or enzyme activity e) Bind with target protein at orthosteric site & inhibit receptor activation or enzyme activity 4
Transcribed Image Text:9. If you were to compare an agonist bound receptor and an antagonist bound receptor Which of the following statements is common to all receptors? a) A channel opens when activated b) There is a conformational change when activated c) The receptor is dimerized when activated d) There are no structural differences 10. Most xenobiotics act transiently and therefore interact with their receptor through weak interactions. Which type of interaction would you not expect to see when examining the receptor ligand interactions for an uncharacterized xenobiotic? a) Van der Waals interactions b) Hydrogen bonds c) Hydrophobic interactions d) All of the above e) None of the above 11. Name the interaction the arrow is pointing to (image to the right): a) Hydrogen Bond b) Pi stacking c) Cation-pi interaction d) Electrostatic interaction H-O 0 NH3 -H 12. Non-competitive antagonists share which of the following characteristics with non-competitive enzyme inhibitors? a) Bind covalently with target protein & permanently inhibit receptor activation or enzyme activity b) Bind reversibly with target protein & effects can be overcome by increasing agonist or substrate concentrations c) Bind irreversibly with target protein & effects can be overcome by increasing agonist or substrate concentrations d) Bind with target protein at allosteric site & inhibit receptor activation or enzyme activity e) Bind with target protein at orthosteric site & inhibit receptor activation or enzyme activity 4
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