5. How will F-2,6-BP levels and flux through gluconeogenesis be affected in the liver of patients with a GK mutation? a. Reduced F-2,6-BP levels and reduced flux through gluconeogenesis b. Reduced F-2,6-BP levels and increased flux through gluconeogenesis Increased F-2,6-BP levels and reduced flux through gluconeogenesis d. Increased F-2,6-BP levels and increased flux through gluconeogenesis C.
5. How will F-2,6-BP levels and flux through gluconeogenesis be affected in the liver of patients with a GK mutation? a. Reduced F-2,6-BP levels and reduced flux through gluconeogenesis b. Reduced F-2,6-BP levels and increased flux through gluconeogenesis Increased F-2,6-BP levels and reduced flux through gluconeogenesis d. Increased F-2,6-BP levels and increased flux through gluconeogenesis C.
Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
Section: Chapter Questions
Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...
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Transcribed Image Text:Patients with a form of early-onset diabetes were found to carry a variety of mutations reducing the function of the
glucokinase (GK) enzyme. These patients are heterozygous for one of the mutations, and thus show only partial
rather than complete loss of GK activity. Answer the following questions about these patients.
How would blood sugar lovolc likoly bo affoctod in CK nautatie
Transcribed Image Text:5. How will F-2,6-BP levels and flux through gluconeogenesis be affected in the liver of patients with a GK
mutation?
a.
Reduced F-2,6-BP levels and reduced flux through gluconeogenesis
b. Reduced F-2,6-BP levels and increased flux through gluconeogenesis
c. Increased F-2,6-BP levels and reduced flux through gluconeogenesis
d. Increased F-2,6-BP levels and increased flux through gluconeogenesis
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