6. Many approaches have been tried for treating human cancers. One approach focuses on therole of ubiquitination in cancer cell biology. Make sure to provide all your citations (submitonline as working URL links).a.Look up the Warburg effect and give a brief summary (one or two paragraphs) abouthow it modifies metabolism in cancer cells.b.Look up the mTORC1 complex and diagram (a pathway approach, not words please)about how it regulates metabolism in normal cells.c.Changes in E3 activity change ubiquitination which in turn modifies protein activity. Howis mTORC1 normally regulated by ubiquitination and how does this change in cancercells?

Cancer cells have a ability to overcome apoptosis. To do so, they overcome autophagy too when there…

Answered: 6. Many approaches have been tried for…

Biochemistry

9th Edition

ISBN:9781319114671

Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Chapter1: Biochemistry: An Evolving Science

Section: Chapter Questions

Problem 1P

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A current focus of molecular medicine is to trigger or promote apoptosis of specific cells. several components of the apoptotic pathways are being targeted using this approach. for each of the following, state specifically how the treatment would be expected to stimulate or inhbit apoptosis. b. exposing cells to recombinant TRAIL protein, a ligand for thr tumor necrosis factor family of receptors
Which of the following drugs would you expect would prevent transformation of cells by the Rous Sarcoma Virus (RSV) (select all that appy)? A. Tyrosine Kinase Inhibitor B. Integrase Inhibitor C. Inhibitor GTPase Activity ✓ D. Reverse Transcriptase Inhibitor E. Staurosporine (inhibitor of Ser/Thr kinases)
Wilms tumor 1, or nephroblastoma, is caused by mutations in the WT1 gene, which encodes a transcription factor. You have identified a novel variant in WT1: Arg422Pro. You have control cells and cells that have been engineered to carry the homozygous WT1 p.Arg422Pro mutation. You want to assess effects of this mutation on a variety of endpoints. For each endpoint listed below, choose the one technique is best suited to answer the question. Choose from: array CGH, qRT-PCR, qPCR, RNA-seq, FISH, in situ hybridization, western blot, immunostaining, WT1 ChIP-seq, WT1 ChIP-PCR, ATAC-seq, 3C Endpoint Technique? WT1 protein amount (quantitative) Western blot WT1 protein binding to all enhancers, genome-wide Chip-seq WT1 mRNA amount (quantitative) WT1 protein subcellular localization Quantitative assessment of all mRNAs in these cells (genome-wide) RNAseq Chromatin interactions between a specific WT1 chromatin binding site (identified above)…
4. You develop the covalently-acting irreversible kinase inhibitor ibrutinib shown on the left that reacts potently with a cysteine in the ATP binding pocket of the cancer-promoting kinase Bruton's Tyrosine Kinase (BTK). You would like to know whether ibrutinib engages and selectively targets BTK in vivo in the tumor of a mouse model of cancer. Describe experimentally how you would use activity-based protein profiling to assess whether ibrutinib inhibited BTK in vivo in the tumor and also determine how selectively ibrutinib engaged BTK compared to other kinases in the tumor? ( NH₂ H₂N- ibrutinib OH OH OH OH OH activity-based probe for kinases that covalently modifies active-site lysine of all kinase ATP binding pocket L W ta to C с
Options for answers in the above picture - pick one. A. H-NS B. IHF C. Histone H1 D. DPS E. Fis
Which of the following statements are correct about the drug Gleevec (select all that apply)? A. Only inhibits activity of transit amplifying cells B. Gleevec is a natural product that was identified in a rare plant C. Negative side effects of drug are inhibition of PDGF and KIT D. Mutations in ABL gene cause resistance to Gleevec E. Inhibits the phosphorylation activity of tyrosine kinase
Select the statement(s) that is(are) NOT true about isozymes a. Isozymes catalyze different reactions b. Isozymes are encoded by different genes c. Isozymes permit fine-tuning of metabolism. d. Isozymes are expressed at different levels in different tissues e. Isozymes show sigmoidal shape activity plots f. Isozymes never result from alternative splicing
76) Nuclear localization signal can be a. Simple sequence in which we have a stretch of acidic amino acid next to each of b. bipartite nuclear localization signal in which we have a stretch of acidic amino are separated by neutral amino acids. c. Simple sequence in which we have a stretch of basic amino acid next to each of d. bipartite nuclear localization signal in which we have a stretch of acidic amino acids then basic amino acids.
BIOCHEMISTRY Which methodologies can be used to detect the expression of a given protein? Please provide pros and cons of each mentioned approach.
The transpeptidase activity of penicillin binding proteins (PBP) promotes: please explain and choice the roght answer a.the addition of N-acetyl glucosamine to N-acetyl muramic acid b.,peptide crosslink formation between murein subunits c.the addition of murein precursors to a growing polymer d.beta lactamase binding to PBP
4). p53 (sometimes called TP53 for “tumor protein 53") is a human tumor suppressor gene that is mutated in the majority of human cancers (many tumor types). a. For each of the mutations described below (i-iv): is this a mutation you would expect to find when sequencing p53 alleles from tumor cells? Why or why not? i. A missense mutation encoding a hyperactive form of the protein. ii. A deletion of the gene. iii. An insertion in the promoter that increases transcription 10-fold. iv. A nonsense mutation. b. When sequencing the p53 gene in tumor cells, would you expect to find only mutant version(s) of the gene or a mix of mutant and wild type versions? c. For any of the mutations you said you would expect to find in tumor cells, would you expect tumor cells to be homozygous (same mutation on both chromosomes)? Why or why not? d. Individuals with Li-Fraumeni syndrome have a very high risk of tumors originating in various tissues due to inheritance of a loss-of-function mutant allele of…
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