6. Many approaches have been tried for treating human cancers. One approach focuses on therole of ubiquitination in cancer cell biology. Make sure to provide all your citations (submitonline as working URL links).a.Look up the Warburg effect and give a brief summary (one or two paragraphs) abouthow it modifies metabolism in cancer cells.b.Look up the mTORC1 complex and diagram (a pathway approach, not words please)about how it regulates metabolism in normal cells.c.Changes in E3 activity change ubiquitination which in turn modifies protein activity. Howis mTORC1 normally regulated by ubiquitination and how does this change in cancercells?

Cancer cells have a ability to overcome apoptosis. To do so, they overcome autophagy too when there…

Answered: 6. Many approaches have been tried for…

Biochemistry

9th Edition

ISBN:9781319114671

Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Chapter1: Biochemistry: An Evolving Science

Section: Chapter Questions

Problem 1P

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Which of the following drugs would you expect would prevent transformation of cells by the Rous Sarcoma Virus (RSV) (select all that appy)? A. Tyrosine Kinase Inhibitor B. Integrase Inhibitor C. Inhibitor GTPase Activity ✓ D. Reverse Transcriptase Inhibitor E. Staurosporine (inhibitor of Ser/Thr kinases)
Wilms tumor 1, or nephroblastoma, is caused by mutations in the WT1 gene, which encodes a transcription factor. You have identified a novel variant in WT1: Arg422Pro. You have control cells and cells that have been engineered to carry the homozygous WT1 p.Arg422Pro mutation. You want to assess effects of this mutation on a variety of endpoints. For each endpoint listed below, choose the one technique is best suited to answer the question. Choose from: array CGH, qRT-PCR, qPCR, RNA-seq, FISH, in situ hybridization, western blot, immunostaining, WT1 ChIP-seq, WT1 ChIP-PCR, ATAC-seq, 3C Endpoint Technique? WT1 protein amount (quantitative) Western blot WT1 protein binding to all enhancers, genome-wide Chip-seq WT1 mRNA amount (quantitative) WT1 protein subcellular localization Quantitative assessment of all mRNAs in these cells (genome-wide) RNAseq Chromatin interactions between a specific WT1 chromatin binding site (identified above)…
4. You develop the covalently-acting irreversible kinase inhibitor ibrutinib shown on the left that reacts potently with a cysteine in the ATP binding pocket of the cancer-promoting kinase Bruton's Tyrosine Kinase (BTK). You would like to know whether ibrutinib engages and selectively targets BTK in vivo in the tumor of a mouse model of cancer. Describe experimentally how you would use activity-based protein profiling to assess whether ibrutinib inhibited BTK in vivo in the tumor and also determine how selectively ibrutinib engaged BTK compared to other kinases in the tumor? ( NH₂ H₂N- ibrutinib OH OH OH OH OH activity-based probe for kinases that covalently modifies active-site lysine of all kinase ATP binding pocket L W ta to C с
Options for answers in the above picture - pick one. A. H-NS B. IHF C. Histone H1 D. DPS E. Fis
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Select the statement(s) that is(are) NOT true about isozymes a. Isozymes catalyze different reactions b. Isozymes are encoded by different genes c. Isozymes permit fine-tuning of metabolism. d. Isozymes are expressed at different levels in different tissues e. Isozymes show sigmoidal shape activity plots f. Isozymes never result from alternative splicing
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76) Nuclear localization signal can be a. Simple sequence in which we have a stretch of acidic amino acid next to each of b. bipartite nuclear localization signal in which we have a stretch of acidic amino are separated by neutral amino acids. c. Simple sequence in which we have a stretch of basic amino acid next to each of d. bipartite nuclear localization signal in which we have a stretch of acidic amino acids then basic amino acids.
BIOCHEMISTRY Which methodologies can be used to detect the expression of a given protein? Please provide pros and cons of each mentioned approach.
28. functional insulin requires the association of two polypeptides known as the A and B chains identify which describes the statement above a. pre-transcriptional controlb. transcriptional controlc. translational controld. post-translational control

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