3. Shown here is the structure of a human gene.exonsintronsTranscription terminationsite (also poly A site)PromoterStart oftranscriptionm25%3'ATG50TACTAA12690130222850132ATT5'a. What is the length of the primary mRNA transcript (before splicing)?b. What is the length of the MRNA after splicingC. How many amino acids will this protein have?d. Where would you find a mutation that affects transcription of this gene?e. Where would you find a mutation that affects splicing?f.What effect would the mutation m2 have on pre-MRNA?g. What effect would mutation m2 have on the length of the mature mRNA?h. What effect would mutation M2 have on the protein produced?

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Human Anatomy & Physiology (11th Edition)

11th Edition

ISBN:9780134580999

Author:Elaine N. Marieb, Katja N. Hoehn

Publisher:Elaine N. Marieb, Katja N. Hoehn

Chapter1: The Human Body: An Orientation

Section: Chapter Questions

Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...

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Similar questions

1. Draw your own version of the Central Dogma below, being sure to include the terms translation, transcription and synthesis. 2. Fill in the following chart regarding the Central Dogma: Transcription Translation Goal (outcome) Required molecules Location where it Occurs Post-event modifications 3. Identify the three main types of RNA and explain the function of each. 4. What is the genetic code and what is it used for?
5. The following questions are about cis-regulatory elements (CRES). a. Describe the role of regulatory elements in eukaryotic gene expression b. What type of CREs are there? c. How do transcription factors 'know' where CREs are?
1. (a)How many amino acids are found in the polypeptide when the mRNA is translated? mRNA 5 - AAUAUGCGGAUGCCCGAA -3 4 5 6 7 (b) "In this mutation, the UGG codon is replaced with UGA." missense mutation nonsense mutation silent mutation frameshift mutation
4. This is the same gene as #1, but with a mutation!! (C/G-T/A at base pair 33) a. Where in the gene is the mutation? (promoter, 5'UTR, 3'UTR, start codon, stop codon, coding region ...) b. Transcribe and translate the gene now What type of mutation is this? C. 5'- CAAATTAATGGCGGCATTTACGATGGTGGGATTATTACATTGACTAACG -3' 5 1 3'- GTTTAATTACCGCCGTAAATGCTACCACCCTAATAATGTAACTGATTGC -5' C. 1 -+ --+-- --+-- 5. This is the same gene as #1, but with a mutation!! (insertion of CG at base pair 29) a. Where in the gene is the mutation? (promoter, 5'UTR, 3'UTR, start codon, stop codon, coding region ...) b. Transcribe and translate the gene now What type of mutation is this? --+-- -+-- 51- CAAATTAATGGEGGO 5'- CAAATTAATGGCGGCATTTACGATGGTGCGGGATCATTACATTGACTAACG -3' 5 -+-- 1 -+- 3'- GTTTAATTACCGCCG 3'- GTTTAATTACCGCCGTAAATGCTACCACGCCCTAGTAATGTAACTGATTGC -5' -+-
9. Identify the TRUE statement about the process of transcription: * ORNA polymerase requires an RNA primer molecule before it can begin transcript ODNA is not needed for the process of transcription. RNA polymerase binds to a promoter region in the DNA to initiate transcription. O During the elongation phase, RNA transcripts are built from 3' to 5'. 10. Which is correct? * Translation occurs in the nucleus; transcription occurs in the cytoplasm O Transcription occurs in the nucleus; translation occurs in the cytoplasm Both transcription and translation take place in the cytoplasm Both transcription and translation occur in the nucleus
6
8. Which of the following gene mutations is most likely to affect correct protein production? The boxes are the exons and the lines are the introns in the gene a. b. C. d. Site 1 Site 2 Explain WHY. 1+ Site 3 Site 4 a two base-pair deletion at Site 1 that removes two "G-C" nucleotide pairs from the gene sequence a single base-pair substitution at Site 2 that changes a tyrosine-encoding amino acid (TAC) to a stop codon (TAA) a single base-pair substitution at Site 3 that changes one alanine-encoding codon (GCC) to another (GCA) a single base-pair insertion at Site 4 that shifts the reading frame for subsequent codons
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4. For the gene drawn below, transcription begins at the boxed A/T base pair. a. Identify the promoter, template and coding strand. b. Transcribe c. Translate 5'- TTGGAATTGTGAATGGATAACAATGTGACACAGGAAACAGCTAAGTAGATGTTT -3' 1 54 3'- AACCTTAACACTTACCTATTGTTACACTGTGTCCTTTGACGATTCATCTACAAA -5' ---+--- ---+--- ---+---- ---+--- ---+---
1. enzymes that catalyze histone acetlation are closesly associated with transription factors, which are proteins that promote transcription. why is this a good biochemical strategy? 2. sp1 is a sqeuence specific human DNA binding protein that binds to a region on the DNA called the GC box, a promoter element with the sequence GGGCGG. Binding of Sp1 to the GC box enhances RNA polymerase 2 activity 50- to a 100 fold. How would you use affinity chromatography to purify SP1?

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