Changes to the nucleotide sequence in the primary transcript (pre-mRNA) may lead to an error in splicing. These types of errors have been implicated in cancers and other human diseases. How would a change in the splicing sequence that prevents the removal of a single intron impact the mature mRNA?

Human Heredity: Principles and Issues (MindTap Course List)
11th Edition
ISBN:9781305251052
Author:Michael Cummings
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Chapter11: Genome Alterations: Mutation And Epigenetics
Section: Chapter Questions
Problem 10QP: If the coding region of a gene (the exons) contains 2,100 base pairs of DNA, would a missense...
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Changes to the nucleotide sequence in the primary transcript (pre-mRNA) may lead to an error in
splicing. These types of errors have been implicated in cancers and other human diseases. How
would a change in the splicing sequence that prevents the removal of a single intron impact the
mature mRNA?
H▾▾ B I A ▾
X₂
X²
2.EE <> 66 X
I
Transcribed Image Text:Changes to the nucleotide sequence in the primary transcript (pre-mRNA) may lead to an error in splicing. These types of errors have been implicated in cancers and other human diseases. How would a change in the splicing sequence that prevents the removal of a single intron impact the mature mRNA? H▾▾ B I A ▾ X₂ X² 2.EE <> 66 X I
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