3) You are investigating the ionic selectivity of an ion channel opened by activation of a specific group of ionotropic receptors. You use the ionic concentrations shown in the following table and determine that the reversal potential for activation of the receptors is -10 mV? Ion Intracellular (mM) Extracellular (mM) Equilibrium Potential (Eton) K+ 140 Na+ 10 145 Ca2+ 0.0001 2 Cl- 6. 106 a) Use the Nernst equation to calculate the equilibrium potential for each ion above. b) Is it likely that ion channel is selective to a single ion? Why or why not? c) Provide one possible ionic selectivity for this channel that could give rise to the following reversal potential. d) How would you determine if this possibility is correct?

Human Anatomy & Physiology (11th Edition)
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3) You are investigating the ionic selectivity of an ion channel opened by activation of a specific group of
ionotropic receptors. You use the ionic concentrations shown in the following table and determine that
the reversal potential for activation of the receptors is -10 mV?
Ion
Intracellular (mM)
Extracellular (mM)
Equilibrium Potential (E1on)
K+
140
5
Na+
10
145
Ca2+
0.0001
2
Cl-
6.
106
a) Use the Nernst equation to calculate the equilibrium potential for each ion above.
b) Is it likely that ion channel is selective to a single ion? Why or why not?
c) Provide one possible ionic selectivity for this channel that could give rise to the following reversal
potential.
d) How would you determine if this possibility is correct?
Transcribed Image Text:3) You are investigating the ionic selectivity of an ion channel opened by activation of a specific group of ionotropic receptors. You use the ionic concentrations shown in the following table and determine that the reversal potential for activation of the receptors is -10 mV? Ion Intracellular (mM) Extracellular (mM) Equilibrium Potential (E1on) K+ 140 5 Na+ 10 145 Ca2+ 0.0001 2 Cl- 6. 106 a) Use the Nernst equation to calculate the equilibrium potential for each ion above. b) Is it likely that ion channel is selective to a single ion? Why or why not? c) Provide one possible ionic selectivity for this channel that could give rise to the following reversal potential. d) How would you determine if this possibility is correct?
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