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Patch clamp recording of a single ion channel yields the following results:         Holding Potential (mV) Measured Current (pA) -100 -1.0 -50 0.0 0 +1.0 +50 +2.0 +100 +3.0 Part a. What is the equilibrium potential for ion X+1? a.) 0 mv  b.)+55 mv c.)-50 mv d.) -60 mv  e.) -75 mv Part b. Is ion X+1 in higher concentration inside or outside the cell? a.) inside  b.) outside  Part c.  Calculate the membrane potential at the instant when a neuron has the following relative permeabilities: PK+ = 1.0, PNa+ = 1.0, PCl- = 1.0.  Use the ionic concentration values in the picture included.  a.) -12 mv  b.) -35mv  c.) -60 mv  d.) +20 mv  e.) 0 mv

Patch clamp recording of a single ion channel yields the following results:         Holding Potential (mV) Measured Current (pA) -100 -1.0 -50 0.0 0 +1.0 +50 +2.0 +100 +3.0 Part a. What is the equilibrium potential for ion X+1? a.) 0 mv  b.)+55 mv c.)-50 mv d.) -60 mv  e.) -75 mv Part b. Is ion X+1 in higher concentration inside or outside the cell? a.) inside  b.) outside  Part c.  Calculate the membrane potential at the instant when a neuron has the following relative permeabilities: PK+ = 1.0, PNa+ = 1.0, PCl- = 1.0.  Use the ionic concentration values in the picture included.  a.) -12 mv  b.) -35mv  c.) -60 mv  d.) +20 mv  e.) 0 mv

Biochemistry
Biochemistry
9th Edition
ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Chapter1: Biochemistry: An Evolving Science
Section: Chapter Questions
Problem 1P
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Patch clamp recording of a single ion channel yields the following results:

       

Holding Potential (mV)

Measured Current (pA)

-100

-1.0

-50

0.0

0

+1.0

+50

+2.0

+100

+3.0

Part a.

What is the equilibrium potential for ion X+1?

a.) 0 mv 

b.)+55 mv

c.)-50 mv

d.) -60 mv 

e.) -75 mv

Part b.

Is ion X+1 in higher concentration inside or outside the cell?

a.) inside 

b.) outside 

Part c. 

Calculate the membrane potential at the instant when a neuron has the following relative permeabilities: PK+ = 1.0, PNa+ = 1.0, PCl- = 1.0.  Use the ionic concentration values in the picture included. 

a.) -12 mv 

b.) -35mv 

c.) -60 mv 

d.) +20 mv 

e.) 0 mv 

lon concentration gradients Na cr) (Cr) K* A Na Na A K* (Cr (cr (Cr) Na Na (Cr) A + K* K* A Cr Nat (Cr) Na Na СГ A K+ A + K* K+ Na A Na K* K* (Cr) Na A A K* (СГ (Cr) A A Na (Cr) K* K+ A СГ Na Na (Cr) (A) Na (Cr A) K K+ K™ A A (Cr) Na Na A K K extracellular sodium (Na*): 144 mM chloride (CI): 144 mM potassium (K*): 5 mM calcium (Ca): 1 mM inorganic anions (A¹): 0 mM intracellular potassium (K): 100 mM organic anions (A¹): 100 mM sodium (Na): 16 mM chloride (CI¯¹): 13 mM calcium (Ca¹2): 0.0001 mM
Transcribed Image Text:lon concentration gradients Na cr) (Cr) K* A Na Na A K* (Cr (cr (Cr) Na Na (Cr) A + K* K* A Cr Nat (Cr) Na Na СГ A K+ A + K* K+ Na A Na K* K* (Cr) Na A A K* (СГ (Cr) A A Na (Cr) K* K+ A СГ Na Na (Cr) (A) Na (Cr A) K K+ K™ A A (Cr) Na Na A K K extracellular sodium (Na*): 144 mM chloride (CI): 144 mM potassium (K*): 5 mM calcium (Ca): 1 mM inorganic anions (A¹): 0 mM intracellular potassium (K): 100 mM organic anions (A¹): 100 mM sodium (Na): 16 mM chloride (CI¯¹): 13 mM calcium (Ca¹2): 0.0001 mM
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