The extracellular sodium [Na+]0 is reduced in the saline bath. Following another current injection in a neuron, the membrane potential changes were recorded. a) Why has the membrane potential changed following the Na+ reduction? b) Why has the current injection produced no action potentials? c) How might you experimentally rescue action potential generation?
The extracellular sodium [Na+]0 is reduced in the saline bath. Following another current injection
in a neuron, the membrane potential changes were recorded.
a) Why has the membrane potential changed following the Na+ reduction?
b) Why has the current injection produced no action potentials?
c) How might you experimentally rescue action potential generation?
Polar large size molecules (glucose, amino acids) and Ions (Na+, H+,k+, Ca+) can't pass easily through the membrane as the membrane is selectively permeable for them. for the transport of ions, ligand-gated and voltage-gated ion channels are required. Permeability barrier and semi permeability of cell membrane are both maintained by lipids. only selective permeability of cell membrane is maintained by membrane proteins. Action potential play important role in signal propagation. for eg, in neuron cells, the generation of action potential propagates signal from neuron axon to the synaptic vesicles present at axon end. Cannel opening and closing depend upon membrane potential rises or drop.
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