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2. John, Paul and Joseph were close friends with a common interest in fitness. John, who had recently started preparing for his first marathon mentioned to his friends that he had started on a low-carbohydrate, protein-rich diet so that he can be muscular but lean. However, Paul said this is actually not a good diet for a marathoner. 2.1. What is Paul's reason for saying that John's diet is not good? 2.2. John's girlfriend Mary also wanted to join the marathon, but was advised by her doctor not to, as she was diabetic. Why would diabetes be a problem for runners?

2. John, Paul and Joseph were close friends with a common interest in fitness. John, who had recently started preparing for his first marathon mentioned to his friends that he had started on a low-carbohydrate, protein-rich diet so that he can be muscular but lean. However, Paul said this is actually not a good diet for a marathoner. 2.1. What is Paul's reason for saying that John's diet is not good? 2.2. John's girlfriend Mary also wanted to join the marathon, but was advised by her doctor not to, as she was diabetic. Why would diabetes be a problem for runners?

Human Anatomy & Physiology (11th Edition)
Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
Section: Chapter Questions
Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...
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2. John, Paul and Joseph were close friends with a common interest in fitness. John, who had recently started preparing for his first marathon mentioned to his friends that he had started on a low-carbohydrate, protein-rich diet so that he can be muscular but lean. However, Paul said this is actually not a good diet for a marathoner. 2.1. What is Paul's reason for saying that John's diet is not good? 2.2. John's girlfriend Mary also wanted to join the marathon, but was advised by her doctor not to, as she was diabetic. Why would diabetes be a problem for runners? 2.3. Joseph, John and Paul decided to join a triathlon. Mary joined them to cheer for John. Unfortunately, a sudden storm sank their boat while they were on their way to the triathlon site. All managed to survive by swimming to a tiny, uninhabited island. They lost all their things, including Mary's insulin. It took three days, with no food or shelter before they were rescued. By then, Mary was already very weak. Based on your knowledge of metabolism, determine the current state of Mary's metabolic pathways (whether active or inactive) in her various organs. Organ Pathway State Liver Glycolysis Gluconeogenesis Glycogen synthesis Fatty acid synthesis Beta-oxidation of FA Muscle Glycolysis Citric Acid cycle Fatty acid synthesis Adipose Glycogen synthesis Fatty acid synthesis 2.4. What would be the expected intracellular levels of the following metabolites in Mary's liver? Indicate whether high, low or normal. Metabolite Level Glucose Ketone bodies Free fatty acids NADH Acetyl-CoA Oxaloacetate 2.5. Overexposure to sunlight has caused a mutation in Joseph's gene coding for glucose-6-phosphatase. Soon after, he became delirious. 2.5.1. What pathway will become inactive because of the mutation? 2.5.2. Explain the consequence of inactivating this pathway and its effects on Joseph.
Transcribed Image Text:2. John, Paul and Joseph were close friends with a common interest in fitness. John, who had recently started preparing for his first marathon mentioned to his friends that he had started on a low-carbohydrate, protein-rich diet so that he can be muscular but lean. However, Paul said this is actually not a good diet for a marathoner. 2.1. What is Paul's reason for saying that John's diet is not good? 2.2. John's girlfriend Mary also wanted to join the marathon, but was advised by her doctor not to, as she was diabetic. Why would diabetes be a problem for runners? 2.3. Joseph, John and Paul decided to join a triathlon. Mary joined them to cheer for John. Unfortunately, a sudden storm sank their boat while they were on their way to the triathlon site. All managed to survive by swimming to a tiny, uninhabited island. They lost all their things, including Mary's insulin. It took three days, with no food or shelter before they were rescued. By then, Mary was already very weak. Based on your knowledge of metabolism, determine the current state of Mary's metabolic pathways (whether active or inactive) in her various organs. Organ Pathway State Liver Glycolysis Gluconeogenesis Glycogen synthesis Fatty acid synthesis Beta-oxidation of FA Muscle Glycolysis Citric Acid cycle Fatty acid synthesis Adipose Glycogen synthesis Fatty acid synthesis 2.4. What would be the expected intracellular levels of the following metabolites in Mary's liver? Indicate whether high, low or normal. Metabolite Level Glucose Ketone bodies Free fatty acids NADH Acetyl-CoA Oxaloacetate 2.5. Overexposure to sunlight has caused a mutation in Joseph's gene coding for glucose-6-phosphatase. Soon after, he became delirious. 2.5.1. What pathway will become inactive because of the mutation? 2.5.2. Explain the consequence of inactivating this pathway and its effects on Joseph.
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