2. A pedigree of a rare disease associated with a mutation (deletion) in a genomie imprintedsutosomal gene is shown below. Individuals with the deletion and disease are shown in color,while those with the deletion but unaffected are indicated by dots. 1 2 I 1 2 II 1 2 3 4 III IV 1 3 4 5 8 V 2 5 8 9 12 13 14 15 1) What type of genomic imprinting is shown, why (1 point)? 2) Given that "A" to represent the normal allele and "A-" to represent the deletion allele, pleasespecify the possible genotype of the labeled individuals (4 points). (From I-1 to V-16,thirty-two in total. You need to distinguish the allele inherited from father and mother) 3) Explain the phenotype of IV-1, IV-2, V-3, V-11, and V-13. (3 points) 4) What is the probability that the offspring of V-5 will exhibit the disease? What about V-14?(2 points)
2. A pedigree of a rare disease associated with a mutation (deletion) in a genomie imprintedsutosomal gene is shown below. Individuals with the deletion and disease are shown in color,while those with the deletion but unaffected are indicated by dots. 1 2 I 1 2 II 1 2 3 4 III IV 1 3 4 5 8 V 2 5 8 9 12 13 14 15 1) What type of genomic imprinting is shown, why (1 point)? 2) Given that "A" to represent the normal allele and "A-" to represent the deletion allele, pleasespecify the possible genotype of the labeled individuals (4 points). (From I-1 to V-16,thirty-two in total. You need to distinguish the allele inherited from father and mother) 3) Explain the
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