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Results are shown above for 3 biallelic SNPs on the same chromosome used in a GWAS examining SNP-trait correlations for a complex human disease trait. Table entries show the number of people with the indicated SNP allele that have the disease (disease group) or don't have the disease (control group). Which SNP would have the highest -log₁0(p-value) score in a Manhattan plot summarizing results of this GWAS, and which is the SNP "risk allele"?

Results are shown above for 3 biallelic SNPs on the same chromosome used in a GWAS examining SNP-trait correlations for a complex human disease trait. Table entries show the number of people with the indicated SNP allele that have the disease (disease group) or don't have the disease (control group). Which SNP would have the highest -log₁0(p-value) score in a Manhattan plot summarizing results of this GWAS, and which is the SNP "risk allele"?

Human Anatomy & Physiology (11th Edition)
Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
Section: Chapter Questions
Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...
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Disease Control group group Allele A 25,350 24,133 Allele C Allele C 24,650 25,867 Allele T SNP1 SNP 2; risk allele is C SNP 3; risk allele is G SNP 2; risk allele is T SNP 3; risk allele is A Results are shown above for 3 biallelic SNPs on the same chromosome used in a GWAS examining SNP-trait correlations for a complex human disease trait. Table entries show the number of people with the indicated SNP allele that have the disease (disease group) or don't have the disease (control group). Which SNP would have the highest -log₁0(p-value) score in a Manhattan plot summarizing results of this GWAS, and which is the SNP "risk allele"? SNP 1; risk allele is A SNP2 SNP 1; risk allele is C Disease Control group group 1,420 1,509 48,580 48,491 SNP3 Allele G Allele A Disease Control group group 47,360 3,109 2,640 46,891
Transcribed Image Text:Disease Control group group Allele A 25,350 24,133 Allele C Allele C 24,650 25,867 Allele T SNP1 SNP 2; risk allele is C SNP 3; risk allele is G SNP 2; risk allele is T SNP 3; risk allele is A Results are shown above for 3 biallelic SNPs on the same chromosome used in a GWAS examining SNP-trait correlations for a complex human disease trait. Table entries show the number of people with the indicated SNP allele that have the disease (disease group) or don't have the disease (control group). Which SNP would have the highest -log₁0(p-value) score in a Manhattan plot summarizing results of this GWAS, and which is the SNP "risk allele"? SNP 1; risk allele is A SNP2 SNP 1; risk allele is C Disease Control group group 1,420 1,509 48,580 48,491 SNP3 Allele G Allele A Disease Control group group 47,360 3,109 2,640 46,891
What conclusion cannot be drawn about the SNP risk allele you identified in the previous question? People with the SNP risk allele are more likely than those without to have the disease The SNP risk allele shares a haplotype with an allele of a gene that increases risk of the disease The SNP risk allele causes an increase in the risk of having the disease The SNP risk allele is associated with the disease
Transcribed Image Text:What conclusion cannot be drawn about the SNP risk allele you identified in the previous question? People with the SNP risk allele are more likely than those without to have the disease The SNP risk allele shares a haplotype with an allele of a gene that increases risk of the disease The SNP risk allele causes an increase in the risk of having the disease The SNP risk allele is associated with the disease
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