13. Flumazenil is the antidote for benzodiazepine overdose, acting as a competitive antagonist at GABAa receptors in the CNS. The effective dose of flumazenil to treat overdose thus depends on which of the following benzodiazepine properties? a) Intrinsic activity and dose b) Receptor affinity and dose c) Selectivity and intrinsic activity d) Selectivity and receptor affinity e) Selectivity and dose

Essentials of Pharmacology for Health Professions
7th Edition
ISBN:9781305441620
Author:WOODROW
Publisher:WOODROW
Chapter16: Gastrointestinal Drugs
Section: Chapter Questions
Problem 16CRQ
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13. Flumazenil is the antidote for benzodiazepine overdose, acting as a competitive antagonist at GABAa
receptors in the CNS. The effective dose of flumazenil to treat overdose thus depends on which of the
following benzodiazepine properties?
a) Intrinsic activity and dose
b) Receptor affinity and dose
c) Selectivity and intrinsic activity
d) Selectivity and receptor affinity
e) Selectivity and dose
Transcribed Image Text:13. Flumazenil is the antidote for benzodiazepine overdose, acting as a competitive antagonist at GABAa receptors in the CNS. The effective dose of flumazenil to treat overdose thus depends on which of the following benzodiazepine properties? a) Intrinsic activity and dose b) Receptor affinity and dose c) Selectivity and intrinsic activity d) Selectivity and receptor affinity e) Selectivity and dose
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