1.Growth factor binding and dimerization Tyrosine kinase domain Growth factor 2. Autophosphorylation Growth factor Grb2 4. Complex assembly Ras GDP SOS (GEF) 3.Binding of adaptor proteins such as Grb2 GDP 5.Guanine nucleotide exchange and activation of Ras GTP Ras GTP Raf 6.Ras binds raf and initiates MAP kinase pathway Is the phosphorylated tyrosine kinase active or inactive? This pathway controls proliferation and cell survival. What is the general type of ligand for tyrosine kinase receptors? What is autophosphorylation?
1.Growth factor binding and dimerization Tyrosine kinase domain Growth factor 2. Autophosphorylation Growth factor Grb2 4. Complex assembly Ras GDP SOS (GEF) 3.Binding of adaptor proteins such as Grb2 GDP 5.Guanine nucleotide exchange and activation of Ras GTP Ras GTP Raf 6.Ras binds raf and initiates MAP kinase pathway Is the phosphorylated tyrosine kinase active or inactive? This pathway controls proliferation and cell survival. What is the general type of ligand for tyrosine kinase receptors? What is autophosphorylation?
Biochemistry
9th Edition
ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Chapter1: Biochemistry: An Evolving Science
Section: Chapter Questions
Problem 1P
Related questions
Question

Transcribed Image Text:Proliferation
Invasion
EGF or TGF-t
P
gogodboogbog
TK
STAT
signalling
Gene transcription
ell-cycle progression
EGFR or other
family members
Angiogenesis
Grb2 Sos
Metastasis
22
Ras
Resistance
to apoptosis
Raf
MEK
MAPK
Proliferation
pathway
1. Growth factor binding
and dimerization
Tyrosine
kinase
domain
Growth factor
TX
2. Autophosphorylation
Growth factor
Coco
P
P
Grb2
4. Complex assembly
Ras GDP
SOS
(GEF)
3.Binding of adaptor proteins
such as Grb2
GDP
5. Guanine nucleotide exchange
and activation of Ras
GTP
Ras GTP
Raf
6.Ras binds raf and initiates
MAP kinase pathway
Is the phosphorylated tyrosine kinase active or inactive?
This pathway controls proliferation and cell survival.
What is the general type of ligand for tyrosine kinase receptors?
What is autophosphorylation?

Transcribed Image Text:8 80
wh
가
Vt
WI
V
N
Messenger
GDP
1
BY
G protein
Receptor
Lumen of
endoplasmic
reticulum
Ca
Membrane of
endoplasmic
reticulum
2
"
GDP GTP
GTP
(5b)
Phospholipase C
PIP 2
3
IP3
DAG
(6c)
Calmodulin
Protein kinase
Protein-P
© 2011 Pearson Education, Inc.
(4a)
6b
Protein kinase C
ATP + protein
Extracellular fluid
(5a)
Response in cell (contraction,
metabolism, transport)
ADP
protein- p
(6a)
Response
in cell
Response in cell
(contraction, secretion)
Cytosol
Which Ga protein activates
phospholipase C?
Which secondary messenger
opens the ligand gated ion
channel?
What does a kinase do?
What does a phosphatase do?
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