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1.Growth factor binding and dimerization Tyrosine kinase domain Growth factor 2. Autophosphorylation Growth factor Grb2 4. Complex assembly Ras GDP SOS (GEF) 3.Binding of adaptor proteins such as Grb2 GDP 5.Guanine nucleotide exchange and activation of Ras GTP Ras GTP Raf 6.Ras binds raf and initiates MAP kinase pathway Is the phosphorylated tyrosine kinase active or inactive? This pathway controls proliferation and cell survival. What is the general type of ligand for tyrosine kinase receptors? What is autophosphorylation?

1.Growth factor binding and dimerization Tyrosine kinase domain Growth factor 2. Autophosphorylation Growth factor Grb2 4. Complex assembly Ras GDP SOS (GEF) 3.Binding of adaptor proteins such as Grb2 GDP 5.Guanine nucleotide exchange and activation of Ras GTP Ras GTP Raf 6.Ras binds raf and initiates MAP kinase pathway Is the phosphorylated tyrosine kinase active or inactive? This pathway controls proliferation and cell survival. What is the general type of ligand for tyrosine kinase receptors? What is autophosphorylation?

Biochemistry
Biochemistry
9th Edition
ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Chapter1: Biochemistry: An Evolving Science
Section: Chapter Questions
Problem 1P
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Proliferation Invasion EGF or TGF-t P gogodboogbog TK STAT signalling Gene transcription ell-cycle progression EGFR or other family members Angiogenesis Grb2 Sos Metastasis 22 Ras Resistance to apoptosis Raf MEK MAPK Proliferation pathway 1. Growth factor binding and dimerization Tyrosine kinase domain Growth factor TX 2. Autophosphorylation Growth factor Coco P P Grb2 4. Complex assembly Ras GDP SOS (GEF) 3.Binding of adaptor proteins such as Grb2 GDP 5. Guanine nucleotide exchange and activation of Ras GTP Ras GTP Raf 6.Ras binds raf and initiates MAP kinase pathway Is the phosphorylated tyrosine kinase active or inactive? This pathway controls proliferation and cell survival. What is the general type of ligand for tyrosine kinase receptors? What is autophosphorylation?
Transcribed Image Text:Proliferation Invasion EGF or TGF-t P gogodboogbog TK STAT signalling Gene transcription ell-cycle progression EGFR or other family members Angiogenesis Grb2 Sos Metastasis 22 Ras Resistance to apoptosis Raf MEK MAPK Proliferation pathway 1. Growth factor binding and dimerization Tyrosine kinase domain Growth factor TX 2. Autophosphorylation Growth factor Coco P P Grb2 4. Complex assembly Ras GDP SOS (GEF) 3.Binding of adaptor proteins such as Grb2 GDP 5. Guanine nucleotide exchange and activation of Ras GTP Ras GTP Raf 6.Ras binds raf and initiates MAP kinase pathway Is the phosphorylated tyrosine kinase active or inactive? This pathway controls proliferation and cell survival. What is the general type of ligand for tyrosine kinase receptors? What is autophosphorylation?
8 80 wh 가 Vt WI V N Messenger GDP 1 BY G protein Receptor Lumen of endoplasmic reticulum Ca Membrane of endoplasmic reticulum 2 " GDP GTP GTP (5b) Phospholipase C PIP 2 3 IP3 DAG (6c) Calmodulin Protein kinase Protein-P © 2011 Pearson Education, Inc. (4a) 6b Protein kinase C ATP + protein Extracellular fluid (5a) Response in cell (contraction, metabolism, transport) ADP protein- p (6a) Response in cell Response in cell (contraction, secretion) Cytosol Which Ga protein activates phospholipase C? Which secondary messenger opens the ligand gated ion channel? What does a kinase do? What does a phosphatase do?
Transcribed Image Text:8 80 wh 가 Vt WI V N Messenger GDP 1 BY G protein Receptor Lumen of endoplasmic reticulum Ca Membrane of endoplasmic reticulum 2 " GDP GTP GTP (5b) Phospholipase C PIP 2 3 IP3 DAG (6c) Calmodulin Protein kinase Protein-P © 2011 Pearson Education, Inc. (4a) 6b Protein kinase C ATP + protein Extracellular fluid (5a) Response in cell (contraction, metabolism, transport) ADP protein- p (6a) Response in cell Response in cell (contraction, secretion) Cytosol Which Ga protein activates phospholipase C? Which secondary messenger opens the ligand gated ion channel? What does a kinase do? What does a phosphatase do?
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