FINAL_LABS_BIOS255_Labs_BIOS_255_Week_5_Immune_System copy

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Middlesex County College *

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255

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Biology

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Jun 22, 2024

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Week 5 Immune System Learning Objectives: Discuss the fundamental need for the immune system. Identify physical and chemical barriers against pathogenic invasion. Describe mechanisms of immune invasion by pathogens. Predict the outcome of scenarios of immune deficiency. Summarize the key features of innate and adaptive immune responses. Describe antigen-antibody interactions. Classify immune cell types by their role in responses. Define immunological memory and its importance. Introduction: Immunity refers to the body's ability to defend itself against disease and infection. Immunity can be categorized into two different forms: innate or adaptive. We will explore the 2 types of immunity. Have you ever wondered what infections look like from the pathogen’s perspective? If our immune systems are so amazing, why do we get sick at all? The immune system is a complex army of cells and tissues that work together to protect your body from infection. In this simulation, you’ll play the part of a pathogen and try to establish an infectious colony within a human body. You will come face to face with the major cells and organs of the immune system. As the immune system fights back, you will gain a unique perspective on how immune cells work to destroy incoming pathogens. By exploring data maps from pivotal moments in human history you will see how an individual’s immunological status contributes to the health of their community and the spread of disease worldwide. You’ll meet the key cells involved in immune memory and explore the role of immunization in protecting people from preventable diseases. You will undertake a series of challenges in preparation for an important global health investigation. Assignment: Part 1 Labster “Introduction to Immunology: Explore the immune system and save the world” As you complete the lab, have the lab report ready to record data. The theory section is a helpful resource. Part 2 Complete the lab report.
Immune System Lab Report 1. Describe components of the immune system by completing the following chart (see theory): (½ point each for total of 3.5 points) Description/Function Innate immunity Has a wide variety of body responses that serve to protect us against invasion by a wide variety of pathogens and their toxins. Adaptive immunity The specific or adaptive immunity responds to a specific pathogen. Is referred to as the second line of defense when the first is incapacitated. IgG Most abundant type of antibody. Produced primarily by memory B cells and plasma cells; circulates freely in the blood plasm and lymphatic fluid. Serves to bind to invading pathogens and other foreign antigens. IgM Control of B cell activation because it is the first line of defense. Binding activity that can pick up trace amounts of infection to mark for recognition of phagocytes. Indicates past infection, which means that there are antibodies developed against a disease. IgA Blood protein that fights off sickness. Protects outside surfaces that are exposed to illness. IgE Found in lungs and mucous membranes. Cause the body to react against foreign substances. Allergic reactions Thymus Produces progenitor cells that mature into T cells that destroy infected or cancerous cells.
2. What is the primary mode by which a macrophage engulfs pathogens? (1/2 point) The primary mode by which macrophages engulf pathogens is phagocytosis. 3. What is a major functional difference between B cells and T cells? (½ point) The major functional difference between B and T cells are: B cells invaders outside the cells T cells attack infected cells 4. Pathogens have been mutating and sharing resistance genes for millions of years. As such they have developed some very effective methods to evade, subvert and destroy the immune response. Identify 2 methods of immune evasion. ( 1/2 point each for total of 1 point) Two methods of immune evasion are: Destroying elements of the immune system Hiding from the immune system 5. Record the data from the samples: (½ point each box for total of 4 points) Antibody detected Sample 1 Sample 3 Sample 7 Sample 8 IgM - + - + IgG + + - - 6. Interpret the results of Samples 1, 3, 7, and 8 by completing the following chart.
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Consider the significance of the presence or absence of IgM and/or IgG. (½ point per box for total of 4 points) Evidence of current exposure/infection? (yes or no) Evidence of previous exposure only with no current infection? (yes or no) Sample 1 No Yes Sample 3 Yes No Sample 7 No No Sample 8 Yes No 7. Discuss the benefit of vaccinations. ( 1 1/2 points) Vaccines aide the immune system in defending the body against viral infections and diseases. Grading Rubric for Lab Report Activity   Deliverable   Points   Part 1 Complete Labster 15 Part 2 Complete lab report 15 Total   Complete all lab activities   30