ANATOMY+PHYSIOLOGY
4th Edition
ISBN: 9781260265217
Author: McKinley
Publisher: RENT MCG
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Textbook Question
Chapter 9.1, Problem 2WDYL
Are all fibrous joints also synarthroses? Explain why or why not.
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Digoxin: Intravenous Bolus - Two Compartment Model
Drug
Digoxin
Route:
IV Bolus
Dose:
0.750 mg
Plasma Concentration Time Profile
Beta
Alpha
Time (hrs)
Conc (ng/ml)
LN
(ng/ml)
LN
(ng/ml)
LN
0.00
#NUM!
#NUM!
#NUM!
0.10
12.290
2.509
#NUM!
#NUMI
0.60
6.975
1.942
#NUM!
#NUMI
1.00
4.649
1.537
#NUM!
#NUMI
2.00
2.201
0.789
#NUM!
#NUM!
3.00
1.536
0.429
#NUM!
#NUM!
4.00
1.342
0.294
#NUM!
#NUM!
5.00
1.273
0.241
#NUM!
#NUMI
6.00
1.238
0.213
#NUM!
#NUM!
7.00
1.212
0.192
#NUM!
#NUM!
8.00
1.188
0.172
#NUMI
#NUM!
9.00
1.165
0.153
#NUM!
#NUMI
10.00
1.143
0.134
#NUMI
#NUM!
11.00
1.122
0.115
#NUM!
12.00
1.101
0.096
#NUMI
13.00
1.080
0.077
#NUMI
16.00
1.020
0.020
#NUMI
24.00
0.876
-0.132
#NUMI
Pharmacokinetic Parameters
Parameter
Value
Alpha
B
Beta
Units
ng/ml
hr-1
ng/ml
hr-1
CO
ng/ml
H.C
AUC
ng x hr/ml
Vc
Vbeta
Vss
C
L/hr
TK (alpha)
hr
TX (beta)
days
5+
F3
F4
F5
0+
F6
F7
%
6
95
14
#3
29
&
t
F8
F9
FW
EW
Linuron, a derivative of urea, is used as an herbicide. Linuron serum levels were measured in 4Kg
rabbits following a bolus IV injection of 10mg/kg.
Time (minutes)
Serum Linuron Levels (ug/ml)
following IV dose
10
15.48
20
8.60
30
5.90
45
3.78
60
2.42
90
1.49
120
0.93
180
0.60
240
0.41
300
0.29
360
0.22
Analyze this data and perform the necessary calculations to determine the following pharmacokinetic
parameters from the IV data: (5 points per parameter, 24 parameters/variables ■ 120 points
possible). You do NOT need to submit graphs or data tables.
Give the terminal regression line equation and R or R² value:
Give the x axis (name and units, if any) of the terminal line:
Give the y axis (name and units, if any) of the terminal line:
Give the residual regression line equation and R or R² value:
Give the x axis (name and units, if any) of the residual line:
Give the y axis (name and units, if any) of the residual line:
Chapter 9 Solutions
ANATOMY+PHYSIOLOGY
Ch. 9.1 - What is the relationship between mobility and...Ch. 9.1 - Are all fibrous joints also synarthroses? Explain...Ch. 9.2 - Prob. 3WDYLCh. 9.2 - Prob. 4WDYLCh. 9.2 - Prob. 5WDYLCh. 9.3 - Prob. 6WDYLCh. 9.3 - Prob. 7WDYLCh. 9.4 - What are the basic characteristics of all types of...Ch. 9.4 - Prob. 9WDYLCh. 9.4 - Prob. 10WDYL
Ch. 9.5 - Prob. 11WDYLCh. 9.5 - Prob. 12WDYLCh. 9.5 - Prob. 13WDYLCh. 9.5 - Prob. 14WDYLCh. 9.6 - Prob. 15WDYLCh. 9.6 - Prob. 16WDYLCh. 9.7 - Prob. 17WDYLCh. 9.7 - Prob. 18WDYLCh. 9.7 - Prob. 19WDYLCh. 9.7 - How do the glenohumeral and hip joints compare...Ch. 9.7 - What are the functions of each of the...Ch. 9.7 - Prob. 22WDYLCh. 9.8 - Prob. 23WDYLCh. 9 - _____ 1. The greatest range of mobility of any...Ch. 9 - _____ 2. A movement of the foot that turns the...Ch. 9 - _____ 3. A _______ is formed when two bones...Ch. 9 - Prob. 4DYKBCh. 9 - Prob. 5DYKBCh. 9 - Prob. 6DYKBCh. 9 - Prob. 7DYKBCh. 9 - Prob. 8DYKBCh. 9 - Prob. 9DYKBCh. 9 - Prob. 10DYKBCh. 9 - Prob. 11DYKBCh. 9 - Prob. 12DYKBCh. 9 - Prob. 13DYKBCh. 9 - How do a hinge joint and a pivot joint compare...Ch. 9 - Prob. 15DYKBCh. 9 - Prob. 16DYKBCh. 9 - Most ankle sprains are overinversion injuries....Ch. 9 - What are the main supporting ligaments of the...Ch. 9 - Prob. 19DYKBCh. 9 - What are the similarities and differences between...Ch. 9 - Prob. 1CALCh. 9 - Prob. 2CALCh. 9 - Prob. 3CALCh. 9 - Prob. 4CALCh. 9 - Prob. 5CALCh. 9 - During soccer practice, Erin tripped over the...Ch. 9 - Prob. 2CSLCh. 9 - Jackie visits her physician because she is...
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