Genetics: From Genes to Genomes, 5th edition
Genetics: From Genes to Genomes, 5th edition
5th Edition
ISBN: 9780073525310
Author: Leland H. Hartwell, Michael L. Goldberg, Janice A. Fischer, Leroy Hood, Charles F. Aquadro
Publisher: McGraw-Hill Education
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Chapter 9, Problem 33P
Summary Introduction

a.

To hypothesize:

The function of a newly synthesized gene having a zinc-finger domain.

Introduction:

A zinc finger is a small, structural motif of a protein. It is characterized by the coordination of one or more zinc ions and thus, stabilize the protein fold. Zinc finger domains have finger-like projections. These projections make a tandem connection with their target molecule.

Summary Introduction

b.

To determine:

The information about the origin of two genes is provided by high percentage of similarity between two genes.

Introduction:

Homologous genes are inherited in two species by a common ancestor. Orthologous are homologous genes which diverge after a specific event. Paralogous genes are homologous genes that evolve by duplication and code for a protein with similar but not identical functions.

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You aim to test the hypothesis that the Tbx4 and Tbx5 genes inhibit each other's expression during limb development. With access to chicken embryos and viruses capable of overexpressing Tbx4 and Tbx5, describe an experiment to investigate whether these genes suppress each other's expression in the limb buds. What results would you expect if they do repress each other? What results would you expect if they do not repress each other?
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Chapter 9 Solutions

Genetics: From Genes to Genomes, 5th edition

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