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The Z value of LOD for two genes is 4, what does it mean for linkage and inheritance?
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- The following pedigree shows the pattern of inheritance of red-green color blindness in a family. Females are shown as circles and males as squares; the squares or circles of individuals affected by the trait are filled in black. What is the chance that a son of the third-generation female indicated by the arrow will be color blind if the father is not color blind? If he is color blind?Individuals of genotype AaBb were mated to individuals of genotype aabb. One thousand offspring were counted, with the following results: 474 Aabb, 480 aaBb, 20 AaBb, and 26 aabb. What type of cross is it? Are these loci linked? What are the two parental classes and the two recombinant classes of offspring? What is the percentage of recombination between these two loci? How many map units apart are they?Hemophilia and color blindness are both recessive conditions caused by genes on the X chromosome. To calculate the recombination frequency between the two genes, you draw a large number of pedigrees that include grandfathers with both hemophilia and color blindness, their daughters (who presumably have one chromosome with two normal alleles and one chromosome with two mutant alleles), and the daughters sons. Analyzing all the pedigrees together shows that 25 grandsons have both color blindness and hemophilia, 24 have neither of the traits, 1 has color blindness only, and 1 has hemophilia only. How many centimorgans (map units) separate the hemophilia locus from the locus for color blindness?
- Imagine that you are performing a cross involving seed texture in garden pea plants. You cross true-breeding round and wrinkled parents to obtain F1 offspring. Which of the following experimental results in terms of numbers of plants are closest to what you expect in the F2 progeny? a. 8lOroundseeds b. 8lOwrinkledseeds c. 405:395 round seeds:wrinkled seeds d. 610:190 round seeds:wrinkled seedsThe text outlines some of the problems Frederick William I encountered in his attempt to breed tall Potsdam Guards. a. Why were the results he obtained so different from those obtained by Mendel with short and tall pea plants? b. Why were most of the children shorter than their tall parents?As it turned out, one of the tallest Potsdam Guards had an unquenchable attraction to short women. During his tenure as guard, he had numerous clandestine affairs. In each case, children resulted. Subsequently, some of the childrenwho had no way of knowing that they were relatedmarried and had children of their own. Assume that two pairs of genes determine height. The genotype of the 7-foot-tall Potsdam Guard was A9A9B9B9, and the genotype of all of his 5-foot clandestine lovers was AABB. An A9 or B9 allele in the offspring each adds 6 inches to the base height of 5 feet conferred by the AABB genotype. a. What were the genotypes and phenotypes of all the F1 children? b. Diagram the cross between the F1 offspring, and give all possible genotypes and phenotypes of the F2 progeny
- You want to determine whether genes a and b are linked. What cross would you use and why? How would this cross tell you if they are linked?Given the karyotype shown at right, is this a male or a female? Normal or abnormal? What would the phenotype of this individual be?Why are monozygotic twins who are reared apart so useful in the calculation of heritability?
- Sunflowers with flowers 10 cm in diameter are crossed with a plant that has 20-cm flowers. The F1 plants have flowers 15 cm in diameter. In the F2 generation, 4 flowers are 10 cm in diameter and 4 are 20 cm in diameter. Between these are 5 phenotypic classes with diameters intermediate to those at the extremes. a. Assuming that the alleles that contribute to flower diameter act additively, how many genes control flower size in this strain of sunflowers? b. How much does each additive allele contribute to flower diameter? c. What size flower makes up the largest phenotypic class?What is independent assortment? Does independent assortment occur during mitosis or during meiosis?Does the phenotype indicated by the red circles and squares in this pedigree show an inheritance pattern that is autosomal dominant, autosomal recessive, or X-linked?
