Genetics: From Genes to Genomes, 5th edition
Genetics: From Genes to Genomes, 5th edition
5th Edition
ISBN: 9780073525310
Author: Leland H. Hartwell, Michael L. Goldberg, Janice A. Fischer, Leroy Hood, Charles F. Aquadro
Publisher: McGraw-Hill Education
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Chapter 9, Problem 21P

Figure 9.11a on p. 318 has numbers indicating the approximate number of millions of years ago that species on separate branches of the tree last shared a common ancestor.

a. About how many millions of years ago did humans last share a common ancestor with chimpanzees, mice, dogs, chickens, and frogs?
These estimates for evolutionary events were obtained in part by comparing the genomic sequences of various current-day species. The basic supposition behind these estimates is that of a molecular clock: Differences in particular types of genomic sequences accumulate at a relatively linear rate during evolutionary time. Consider the three following kinds of nucleotide changes: (i) missense mutations in coding regions that alter amino acid identity; (ii) silent (synonymous) mutations that change a codon for a particular amino acid into a different codon for the same amino acid; and (iii) mutations in introns. Which of the three types of mutations would . . .
b. . . . represent the slowest-ticking clock? (That is, which type of mutation would accumulate the least rapidly in genomes? Hint: See Fig. 9.12 on p. 318.)
c. . . . you most likely use to estimate the divergence times of species that last shared a common ancestor more than 400 million years ago?
d. . . . be most likely to vary in the rate at which they would accumulate in different genes?

Chapter 9, Problem 21P, Figure 9.11a on p. 318 has numbers indicating the approximate number of millions of years ago that

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