Concept explainers
The nucleus is one of the largest organelles in the cell and that contains chromosomes. Eukaryotic chromosomes are composed of a complex of DNA and protein structure is known as chromatin. The chromatin structure serves for the packing and condensation of DNA molecules, thereby; the large size of DNA molecules can be inserted into the cell. There are five histone proteins are found in eukaryotes such as H1, H2A, H2B, H3, and H4. Eight molecules of histones create a structure called an ellipsoid containing 11 nm in long and 6.5-7 nm in diameter. The DNA wraps around the ellipsoid and produces a “beads on a string” formation. Each bead is known as a nucleosome. The highly compacted structure of the chromosome is found during cell division. Histones proteins and other molecules, mainly contribute to the compact structure of chromosomes.
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Prescott's Microbiology
- Changes in chromatin packing correlate with changes in gene expression in most cells. Why do you think this is the case?arrow_forwardHistones can be modified to turn genes on and off. Which type of chromatin is associated with transcriptionally active regions of the DNA?arrow_forwardConsider how histone proteins bind to DNA and then explain whya high salt concentration can remove histones from DNA (asshown in 10.18b).arrow_forward
- What is the importance of the histone proteins present in the nucleus?arrow_forwardDescribe the mechanism by which histone modifications are established after DNA replication and cell division. What are some things that could go wrong if modifications can't be maintained? Think about what histone modifications do to DNA and why cells maintain parts of their chromosome as heterochromatin.arrow_forwardWhich one of the following statements about nucleosomes is false? a) The DNA double helix wraps around the nucleosome. b) The sequence of amino acid in a histone tail is altered during chromatin remodeling. c) A nucleosome is composed of 8 histone proteins; two copies of each type of histone. d) A large percent of the nucleosome is positively charged.arrow_forward
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