Biology 2e
2nd Edition
ISBN: 9781947172517
Author: Matthew Douglas, Jung Choi, Mary Ann Clark
Publisher: OpenStax
expand_more
expand_more
format_list_bulleted
Concept explainers
Videos
Textbook Question
Chapter 42, Problem 2VCQ
Figure 42.14 Based on what you know about MHC receptors, why do you think an organ transplanted
from an incompatible donor to a recipient will be rejected?
Expert Solution & Answer
Trending nowThis is a popular solution!
Students have asked these similar questions
What occurs in a cell-mediated immune response? Select all that apply.
Naive B cells bind to antigen on the surface of a bacterium and become activated.
A dendritic cell incorporates digested viral antigen-MHC complexes.
Naive cytotoxic T cells bind to antigen on antigen-presenting dendritic cells and become activated.
Effector cytotoxic T cells circulate through the body and kill any body cells that display the viral antigen-MHC complexes.
Which of the following best defines MHC restriction?
Select one:
a. The TCR recognizes a particular epitope in the context of a specific MHC molecule.
b. Any given MHC molecule is able to bind a wide variety of epitopes.
C. The TCR recognizes only the MHC molecule.
Od.
The TCR recognizes the epitope bound to any MHC molecule having the correct motif.
Oe. A TCR may bind to either an MHC Class I or MHC Class II molecule along with the bound epitope.
The virus shown in the diagram below is only able to infect and replicate in epithelial cells. In order for the cross-presenting dendritic cell to display viral peptides, rather than self peptides on its surface MHC class I proteins, which of the following procedures could be utilized, starting with the components shown in the figure below?
Mix epithelial cells with heat-killed virus, wait 24 hrs, wash away any virus particles outside the epithelial cells, then add epithelial cells to dendritic cells.
Mix epithelial cells with viral peptides, wait 24 hrs, wash away any viral peptides not bound to the epithelial cells, then add epithelial cells to dendritic cells.
Mix epithelial cells with live virus particles, wait 24 hrs, wash away any virus particles outside the epithelial cells, then add epithelial cells to dendritic cells.
Mix dendritic cells with viral nucleic acids and epithelial cells for 24 hrs.
MIx epithelial cells will viral nucleic acids, wait 24 hrs, wash away any viral…
Chapter 42 Solutions
Biology 2e
Ch. 42 - Figure 42.11 Which of the following statements...Ch. 42 - Figure 42.14 Based on what you know about MHC...Ch. 42 - Figure 42.16 The Rh antigen is found on Rh...Ch. 42 - Which of the following is a barrier against...Ch. 42 - Although interferons have several effects, they...Ch. 42 - Which organelle do phagocytes use to digest...Ch. 42 - Which innate immune system component uses MHC I...Ch. 42 - Which of the following is both a phagocyte and an...Ch. 42 - Which immune cells bind MHC molecules on APCs via...Ch. 42 - What “self” pattern is identified by NK cells?...
Ch. 42 - The acquired ability to prevent an unnecessary or...Ch. 42 - A memory B cell can differentiate upon reexposure...Ch. 42 - Foreign particles circulating in the blood are...Ch. 42 - The structure of an antibody is similar to the...Ch. 42 - The first antibody class to appear in the serum in...Ch. 42 - What is the most abundant antibody class detected...Ch. 42 - Breastfed infants typically are resistant to...Ch. 42 - Allergy to pollen is classified as: an autoimmune...Ch. 42 - A potential cause of acquired autoimmunity is...Ch. 42 - Autoantibodies are probably involved in: reactions...Ch. 42 - Which of the following diseases is not due to...Ch. 42 - Different MHC I molecules between donor and...Ch. 42 - If a series of genetic mutations prevented some,...Ch. 42 - Explain the difference between an epitope and an...Ch. 42 - What is a naïve B or T cell?Ch. 42 - How does the Th1 response differ from the Th2...Ch. 42 - In mammalian adaptive immune systems, T cell...Ch. 42 - How do B and T cells differ with respect to...Ch. 42 - Why is the immune response after reinfection much...Ch. 42 - What are the benefits and costs of antibody cross...
Additional Science Textbook Solutions
Find more solutions based on key concepts
Researchers cross a corn plant that is pure - breeding forthe dominant traits colored aleurone (C1), full kerne...
Genetic Analysis: An Integrated Approach (3rd Edition)
2. Define equilibrium population. Outline the conditions that must be met for a population to stay in genetic e...
Biology: Life on Earth (11th Edition)
Your bore cells, muscle cells, and skin cells look different because a. different kinds of genes are present in...
Campbell Essential Biology (7th Edition)
Which clade does not include humans? (A)synapsids (B)lobe-fins (C) diapsids (D) osteichthyans
Campbell Biology (11th Edition)
1. Which parts of the skeleton belong to the appendicular skeleton? Which belong to the axial skeleton?
Human Anatomy & Physiology (2nd Edition)
What is the difference between cellular respiration and external respiration?
Human Physiology: An Integrated Approach (8th Edition)
Knowledge Booster
Learn more about
Need a deep-dive on the concept behind this application? Look no further. Learn more about this topic, biology and related others by exploring similar questions and additional content below.Similar questions
- Figure 42.11 Which of the following statements about T cells is false? Helper T cells release cytokines while cytotoxic T cells kill the infected cell. Helper T cells are CD4+, while cytotoxic T cells are CD8+. MHC II is a receptor found on most body cells, while MHC I is a receptor found on immune cells only. The T cell receptor is found on both CD4+ and CD8+ T cells.arrow_forwardYou are studying SARS-COV2. You identify a viral protein that results in the decrease of MHC class I, a cell surface receptor, on the cell surface. You are trying to determine the mechanism for how the virus is decreasing cell surface MHC I. You decide to do an experiment to determine whether the receptor is making it all of the way through the secretory pathway. You take two samples of cells. 1. Uninfected 2. Infected with SARS-CoV2 You treat them with EndoH and analyze MHC I on a western blot and get the following results: 1. Uninfected cells - 50% of protein is endo H sensitive and 50% is Endo H resistant 2. SARS-COV2 infected cells - 100% of protein is Endo H sensitive How would you best interpret these results? Is MHC I going all the way through the secretory pathway in infected cells? A. No, MHC I is not going all the way through the secretory pathway. 100% of the protein is EndoH sensitive in infected cells, this means that the virus is somehow inhibiting the protein from making…arrow_forwardWhy would a virus that can interfere with a host cell’s production of MHC class I molecules be at an advantage?arrow_forward
- You can choose one or more than one option Antibodies: IMMUNOLOGY basic have two identical antigen-binding sites. consist of two identical heavy chains and two identical light chains. are secreted by plasma cells are produced by T lymphocytes during adaptive immune response can bind their constant heavy chain region to phagocytes Which of the following proteins are transmembrane proteins? CELL BIOLOGY basic integrin oestrogen receptor phospholipase C adenosine triphosphate (ATP) synthase growth factor receptor What are the correct statements? MOLECULAR BIOLOGY advanced A mutation located within a promoter can change the gene expression. An mRNA can be differentially spliced according to the tissue. RNA transcribed by the RNA polymerase II are translated The end of the transcription process requires a specific DNA sequence A reverse transcriptase can polymerise either a DNA or an RNA strand. Which of the following cells kill other cells by exocytosis of…arrow_forwardWhich of the following steps are part of the processing of antigen by immune cells? Select all that apply.arrow_forwardWhere is the CD4 receptor? What is it’s role in the immune response? (provide details – innate vs acquired) Why is someone lacking the CD4 receptor immune to HIV infection?arrow_forward
- Some strains of the human papilloma virus (HPV) are resistant to interferons. If HPV can inhibit interferon binding to cells, what advantage does this give the virus? Question 2 options: Antiviral proteins will not be synthesized in neighbouring cells. Interferons will be released by non-infected neighbouring cells. Interferons will bind to the virus to neurtralize it. Interferons tell the virus-infected cells to apoptose. The viruses will be warned that a host is coming.arrow_forwardIn general terms, what role do cytokines play in the development of immunity? How does this compare with chemokines?arrow_forwardInhibitory receptors on lymphocytes down-regulate immune responses by recruiting protein or lipid phosphatases.BCR signaling on B cells is initiated by antigen binding, leading to mTOR activation. This occurs, for instance, when the antigen is a live microbe that binds to the BCR on the B cells. Which one of the forms of antigen shown below the graph would correctly account for the data shown in the figure?arrow_forward
- APC cells with antigen presented on MHC I can trigger which naïve cell type to activate, thus forming memory and effector cells? O 1) macrophages O 2) CD4 cells O 3) CD8 cells O 4) B cellsarrow_forwardWhich of the following steps are part of the processing of antigen by immune cells? Select all that apply. The vesicle containing the antigen fuses with a lysosome. Enzymes in the lysosome digest the antigen into components that bind to MHC markers. The antigen is initially released from the phagocytic cell via exocytosis. The antigen-MHC complex becomes displayed on the cell's interior.arrow_forwardWhich of the following cells would be safe from a natural killer (NK) cell's cytotoxicity? I selected "a self-cell without MHC I molecules" which is incorrect. Please help.arrow_forward
arrow_back_ios
SEE MORE QUESTIONS
arrow_forward_ios
Recommended textbooks for you
- Biology 2eBiologyISBN:9781947172517Author:Matthew Douglas, Jung Choi, Mary Ann ClarkPublisher:OpenStax
Biology 2e
Biology
ISBN:9781947172517
Author:Matthew Douglas, Jung Choi, Mary Ann Clark
Publisher:OpenStax
What is cancer? What causes cancer and how is it treated? *UPDATE*; Author: Cancer Treatment Centers of America - CTCA;https://www.youtube.com/watch?v=_N1Sk3aiSCE;License: Standard Youtube License