Biochemistry
Biochemistry
8th Edition
ISBN: 9781464126109
Author: Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr., Lubert Stryer
Publisher: W. H. Freeman
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Chapter 4, Problem 1P
Interpretation Introduction

Interpretation:

The difference between nucleoside and nucleotide should be determined.

Concept introduction:

The building blocks of nucleic acids (DNA and RNA) are nucleotides. The nucleotide is composed of sugar (ribose or deoxyribose), nitrogenous base, and phosphate group that are bonded covalently whereas the removal of phosphate group from nucleotide by hydrolysis results in the formation of nucleoside.

Expert Solution & Answer
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Answer to Problem 1P

Nucleoside is composed of sugar (ribose or deoxyribose) and base whereas nucleotide is composed of sugar (ribose or deoxyribose), base and phosphate.

Explanation of Solution

Nucleoside consists of nitrogen base along with sugar (ribose or deoxyribose) but without phosphate.

A nucleoside has sugar along with base components.

Nucleotide includes one or more phosphate groups attached to a nitrogen base.

Sugar molecules in nucleoside and nucleotide are either ribose or deoxyribose.

The removal of phosphate group from nucleotide by hydrolysis results in the formation of nucleoside.

A nucleoside is used as medicine, antiviral or anticancer agents which is important for optimal health.

Nucleotide is often used in energy sources, sequencing signal pathways.

Conclusion

Nucleosides are nitrogen-based compounds without phosphate groups attached to sugar whereas nucleotides have one to three phosphate groups attached to nitrogenous base and sugar. A nucleotide is nothing but nucleoside which binds phosphate groups.

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