Biochemistry: The Molecular Basis of Life
Biochemistry: The Molecular Basis of Life
6th Edition
ISBN: 9780190209896
Author: Trudy McKee, James R. McKee
Publisher: Oxford University Press
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Chapter 3, Problem 64TQ
Summary Introduction

To review:

The carboxylic acid group present in a water-free interior of a protein has a higher or lower Ka(acid dissociation constant), than on the surface of the protein.

Introduction:

In biochemistry, acid dissociation constant or Ka is defined as a type of equilibrium constant that measures the tendency of a larger molecule to dissociate reversibly into smaller molecules. Carboxylic acid groupsionize to a lesser extent in water to form moderately acidic solutions. Carboxylic acids have -COOH as the functional group, and a Ka constant of about 10-3  to 10-6 .

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Biochemistry: The Molecular Basis of Life

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