Explanation Bicarbonate buffer is an important buffer in the blood. This buffer has three components. When excessive amounts of carbonic acid are produced, the kidney excretes the bicarbonate. In case of secretory diarrhea, the bicarbonate buffer equation changes. It has been given in the question that in severe diarrhe, a large quantity of sodium bicarbonate is lost (NaHCO 3 ). Such a condition in which loss of NaHCO 3 takes place is termed as “ metabolic acidosis”. This is one of the acid-base disorders which is common in animals. In this condition, left shift of bicarbonate buffer equation is observed which has been depicted in the equation given below:

Biochemistry: The Molecular Basis of Life

6th Edition

ISBN: 9780190209896

Author: Trudy McKee, James R. McKee

Publisher: Oxford University Press

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Question

Chapter 3, Problem 4Q

Summary Introduction

To review:

The direction of bicarbonate buffer (system) shift in the case of severe diarrhea, and also, to name the resulting condition.

Introduction:

When abnormal fluid secretion occurs in small bowe, lhis results into secretory diarrhea. In such condition, dehydration is caused as sodium absorption by villi becomes impaired while chloride ion secretion in crypts is increased. This results in the loss of water and salt from the body.

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Solution Summary: The author explains the direction of bicarbonate buffer (system) shift in the case of severe diarrhea.

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