Fundamentals of Biostatistics
8th Edition
ISBN: 9781305268920
Author: Bernard Rosner
Publisher: Cengage Learning
expand_more
expand_more
format_list_bulleted
Concept explainers
Videos
Textbook Question
thumb_up100%
Chapter 3, Problem 64P
Genetics, Obstetrics
Precise quantification of smoking during pregnancy is difficult in retrospective studies. Routinely collected blood specimens from newborns for screening purposes may provide a low-cost method to objectively measure maternal smoking close to the time of delivery. Serum cotinine is an important biomarker of recent smoking. A study was performed comparing cotinine levels in dried blood spots in newborns with those in umbilical cord blood (the gold standard) among 428 newborns in the California Genetic Screening Program (Yang et al. [11]). The lowest detection limit for dried blood spot cotinine was 3.1 ng/mL. The data in Table 3.9 were presented relating dried blood spot cotinine determinations to umbilical cord blood cotinine determinations.
Suppose a cutoff of ≥ 5 ng/mL is proposed as a criterion for testing positive based on dried blood spot cotinine levels.
What is the sensitivity using this cut-point?
TABLE 3.9 Distribution of Cotinine Level in Dried Blood Spots from Newborns by Maternal Active Smoking Status* close to the time of delivery among 428 babies delivered in California, 2001–2003
Expert Solution & Answer
Want to see the full answer?
Check out a sample textbook solution
Chapter 3 Solutions
Fundamentals of Biostatistics
Ch. 3.6 - What is the frequency definition of probability?Ch. 3.6 - What is the difference between independent and...Ch. 3.6 - What are mutually exclusive events?Ch. 3.6 - What is the addition law of probability?Ch. 3.6 - What is conditional probability? How does it...Ch. 3.6 - What is relative risk? How do you interpret it?Ch. 3.6 - Prob. B.1RECh. 3.6 - Suppose the rate of type II diabetes mellitus (DM)...Ch. 3.7 - What is the sensitivity and specificity of a...Ch. 3.7 - What are the PV+ and PV of a screening test? How...
Ch. 3.7 - Prob. C.3RECh. 3.7 - What is Bayes rule? How is it used?Ch. 3.7 - Prob. D.2RECh. 3.7 - Prob. D.3RECh. 3.7 - Prob. D.4RECh. 3.10 - Suppose that of 25 students in a class, 5 are...Ch. 3.10 - Suppose 50 HIV-positive men are identified, 5 of...Ch. 3 - Consider a family with a mother, father, and two...Ch. 3 - Consider a family with a mother, father, and two...Ch. 3 - Consider a family with a mother, father, and two...Ch. 3 - Consider a family with a mother, father, and two...Ch. 3 - Consider a family with a mother, father, and two...Ch. 3 - Consider a family with a mother, father, and two...Ch. 3 - Consider a family with a mother, father, and two...Ch. 3 - Consider a family with a mother, father, and two...Ch. 3 - Consider a family with a mother, father, and two...Ch. 3 - Consider a family with a mother, father, and two...Ch. 3 - Prob. 11PCh. 3 - Suppose an influenza epidemic strikes a city. In...Ch. 3 - Suppose there is a 20% chance each child will get...Ch. 3 - Suppose there is a 20% chance each child will get...Ch. 3 - Suppose there is a 20% chance each child will get...Ch. 3 - Mental Health Estimates of the prevalence of...Ch. 3 - Mental Health Estimates of the prevalence of...Ch. 3 - Mental Health Estimates of the prevalence of...Ch. 3 - Mental Health Estimates of the prevalence of...Ch. 3 - Estimates of the prevalence of Alzheimers disease...Ch. 3 - Estimates of the prevalence of Alzheimers disease...Ch. 3 - Estimates of the prevalence of Alzheimers disease...Ch. 3 - Estimates of the prevalence of Alzheimers disease...Ch. 3 - Estimates of the prevalence of Alzheimers disease...Ch. 3 - Estimates of the prevalence of Alzheimers disease...Ch. 3 - Suppose a study of Alzheimers disease is proposed...Ch. 3 - Suppose a study of Alzheimers disease is proposed...Ch. 3 - Commonly used vaccines for influenza are trivalent...Ch. 3 - Prob. 29PCh. 3 - Prob. 30PCh. 3 - Prob. 31PCh. 3 - Genetics Suppose that a disease is inherited via a...Ch. 3 - Genetics Suppose that a disease is inherited via a...Ch. 3 - Genetics Suppose that a disease is inherited via a...Ch. 3 - Prob. 35PCh. 3 - Prob. 36PCh. 3 - Suppose that a disease is inherited via an...Ch. 3 - Suppose that a disease is inherited via an...Ch. 3 - Prob. 39PCh. 3 - Suppose that a disease is inherited via a...Ch. 3 - Suppose that a disease is inherited via a...Ch. 3 - Suppose that a disease is inherited via a...Ch. 3 - Suppose that a disease is inherited via a...Ch. 3 - Prob. 44PCh. 3 - Prob. 45PCh. 3 - Prob. 46PCh. 3 - Prob. 47PCh. 3 - Prob. 48PCh. 3 - Prob. 49PCh. 3 - Obstetrics The following data are derived from the...Ch. 3 - Obstetrics The following data are derived from the...Ch. 3 - Obstetrics The following data are derived from the...Ch. 3 - Pulmonary Disease The familial aggregation of...Ch. 3 - Pulmonary Disease The familial aggregation of...Ch. 3 - Suppose, alternatively, that if the father is a...Ch. 3 - Suppose, alternatively, that if the father is a...Ch. 3 - Prob. 57PCh. 3 - The familial aggregation of respiratory disease is...Ch. 3 - The familial aggregation of respiratory disease is...Ch. 3 - The familial aggregation of respiratory disease is...Ch. 3 - The familial aggregation of respiratory disease is...Ch. 3 - Pulmonary Disease The familial aggregation of...Ch. 3 - Pulmonary Disease The familial aggregation of...Ch. 3 - Genetics, Obstetrics Precise quantification of...Ch. 3 - Precise quantification of smoking during pregnancy...Ch. 3 - Precise quantification of smoking during pregnancy...Ch. 3 - What is another name for this quantity? Suppose it...Ch. 3 - Research into cigarette-smoking habits, smoking...Ch. 3 - Research into cigarette-smoking habits, smoking...Ch. 3 - Research into cigarette-smoking habits, smoking...Ch. 3 - Research into cigarette-smoking habits, smoking...Ch. 3 - Research into cigarette-smoking habits, smoking...Ch. 3 - Research into cigarette-smoking habits, smoking...Ch. 3 - Pulmonary Disease Research into cigarette-smoking...Ch. 3 - Pulmonary Disease Research into cigarette-smoking...Ch. 3 - Laboratory measures of cardiovascular reactivity...Ch. 3 - Laboratory measures of cardiovascular reactivity...Ch. 3 - Laboratory measures of cardiovascular reactivity...Ch. 3 - The data set in Table 3.12 is based on 214...Ch. 3 - The data set in Table 3.12 is based on 214...Ch. 3 - The data set in Table 3.12 is based on 214...Ch. 3 - A drug company is developing a new pregnancy-test...Ch. 3 - A drug company is developing a new pregnancy-test...Ch. 3 - A drug company is developing a new pregnancy-test...Ch. 3 - Gynecology A drug company is developing a new...Ch. 3 - The Chinese Mini-Mental Status Test (CMMS)...Ch. 3 - The Chinese Mini-Mental Status Test (CMMS)...Ch. 3 - Mental Health The Chinese Mini-Mental Status Test...Ch. 3 - Construct an ROC curve based on the table...Ch. 3 - Mental Health The Chinese Mini-Mental Status Test...Ch. 3 - Calculate the area under the ROC curve. Interpret...Ch. 3 - Demography A study based on data collected from...Ch. 3 - Prob. 94PCh. 3 - Demography A study based on data collected from...Ch. 3 - Demography A study based on data collected from...Ch. 3 - Prob. 97PCh. 3 - The 4 allele of the gene encoding apolipoprotein E...Ch. 3 - Mental Health The 4 allele of the gene encoding...Ch. 3 - Mental Health The 4 allele of the gene encoding...Ch. 3 - Cardiovascular Disease A fascinating subject of...Ch. 3 - Cardiovascular Disease A fascinating subject of...Ch. 3 - Are these proportions prevalence rates, incidence...Ch. 3 - Prob. 104PCh. 3 - A dominantly inherited genetic disease is...Ch. 3 - A dominantly inherited genetic disease is...Ch. 3 - Prob. 107PCh. 3 - Infectious Disease, Cardiovascular Disease A...Ch. 3 - Infectious Disease, Cardiovascular Disease A...Ch. 3 - Infectious Disease, Cardiovascular Disease A...Ch. 3 - Prob. 114PCh. 3 - Genetics Suppose a birth defect has a recessive...Ch. 3 - A further study finds that after 10 generations...Ch. 3 - A further study finds that after 10 generations...Ch. 3 - Orthopedics Piriformis syndrome is a pelvic...Ch. 3 - Prob. 119PCh. 3 - Orthopedics Piriformis syndrome is a pelvic...Ch. 3 - Prob. 121PCh. 3 - Cancer Breast cancer is considered largely a...Ch. 3 - Cancer Breast cancer is considered largely a...Ch. 3 - Cancer Breast cancer is considered largely a...Ch. 3 - Prob. 125PCh. 3 - Cardiovascular Disease Mayo Clinic investigators...Ch. 3 - Prob. 127PCh. 3 - Prob. 128PCh. 3 - Prob. 129PCh. 3 - Prob. 130PCh. 3 - Prob. 131PCh. 3 - Prob. 132PCh. 3 - Radiology Mobile displays have the potential to...Ch. 3 - Radiology Mobile displays have the potential to...Ch. 3 - Prob. 135PCh. 3 - Prob. 136PCh. 3 - Prob. 137PCh. 3 - Cardiovascular Disease The ankle-arm...Ch. 3 - Cardiovascular Disease The ankle-arm...Ch. 3 - Cardiovascular Disease The ankle-arm...Ch. 3 - Prob. 141PCh. 3 - Prob. 142PCh. 3 - Prob. 143PCh. 3 - Obstetrics, Health Promotion A study was performed...
Knowledge Booster
Learn more about
Need a deep-dive on the concept behind this application? Look no further. Learn more about this topic, statistics and related others by exploring similar questions and additional content below.Statistics 4.1 Point Estimators; Author: Dr. Jack L. Jackson II;https://www.youtube.com/watch?v=2MrI0J8XCEE;License: Standard YouTube License, CC-BY
Statistics 101: Point Estimators; Author: Brandon Foltz;https://www.youtube.com/watch?v=4v41z3HwLaM;License: Standard YouTube License, CC-BY
Central limit theorem; Author: 365 Data Science;https://www.youtube.com/watch?v=b5xQmk9veZ4;License: Standard YouTube License, CC-BY
Point Estimate Definition & Example; Author: Prof. Essa;https://www.youtube.com/watch?v=OTVwtvQmSn0;License: Standard Youtube License
Point Estimation; Author: Vamsidhar Ambatipudi;https://www.youtube.com/watch?v=flqhlM2bZWc;License: Standard Youtube License