Fundamentals of Biostatistics
8th Edition
ISBN: 9781305268920
Author: Bernard Rosner
Publisher: Cengage Learning
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Chapter 3, Problem 100P
Mental Health
The ε4 allele of the gene encoding apolipoprotein E (APOE) is strongly associated with Alzheimer’s disease, but its value in making the diagnosis remains uncertain. A study was conducted among 2188 patients who were evaluated at autopsy for Alzheimer’s disease by previously established pathological criteria [16]. Patients were also evaluated clinically for the presence of Alzheimer’s disease. The data in Table 3.15 were presented.
Suppose the pathological diagnosis is considered the gold standard for Alzheimer’s disease.
To possibly improve on the diagnostic accuracy of the clinical diagnosis for Alzheimer’s disease, information on both the APOE genotype as well as the clinical diagnosis were considered. The data are presented in Table 3.16.
Suppose we consider the combination of both a clinical diagnosis for Alzheimer’s disease and the presence of ≥ 1 ε4 allele as a screening test for Alzheimer’s disease.
Table 3.15 Relationship between clinical and pathological diagnoses of Alzheimer’s disease
Table 3.16 Influence of the APOE genotype in diagnosing Alzheimer’s disease (AD)
What is the specificity of this test?
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Chapter 3 Solutions
Fundamentals of Biostatistics
Ch. 3.6 - What is the frequency definition of probability?Ch. 3.6 - What is the difference between independent and...Ch. 3.6 - What are mutually exclusive events?Ch. 3.6 - What is the addition law of probability?Ch. 3.6 - What is conditional probability? How does it...Ch. 3.6 - What is relative risk? How do you interpret it?Ch. 3.6 - Prob. B.1RECh. 3.6 - Suppose the rate of type II diabetes mellitus (DM)...Ch. 3.7 - What is the sensitivity and specificity of a...Ch. 3.7 - What are the PV+ and PV of a screening test? How...
Ch. 3.7 - Prob. C.3RECh. 3.7 - What is Bayes rule? How is it used?Ch. 3.7 - Prob. D.2RECh. 3.7 - Prob. D.3RECh. 3.7 - Prob. D.4RECh. 3.10 - Suppose that of 25 students in a class, 5 are...Ch. 3.10 - Suppose 50 HIV-positive men are identified, 5 of...Ch. 3 - Consider a family with a mother, father, and two...Ch. 3 - Consider a family with a mother, father, and two...Ch. 3 - Consider a family with a mother, father, and two...Ch. 3 - Consider a family with a mother, father, and two...Ch. 3 - Consider a family with a mother, father, and two...Ch. 3 - Consider a family with a mother, father, and two...Ch. 3 - Consider a family with a mother, father, and two...Ch. 3 - Consider a family with a mother, father, and two...Ch. 3 - Consider a family with a mother, father, and two...Ch. 3 - Consider a family with a mother, father, and two...Ch. 3 - Prob. 11PCh. 3 - Suppose an influenza epidemic strikes a city. 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