Chapter 26, Problem 28CQ

Summary Introduction

To explain: The reason why the protein in human cells that bind to the 5ʹ triphosphate groups of RNA would be part of the defense against viral infection.

Introduction: In humans, the innate immune system forms the first line of defense against infections caused by viruses and other microbes. Retinoic acid-inducible protein I (RIG-I) binds to the 5ʹ triphosphate groups of RNA molecules. They recognize free 5ʹ triphosphate groups and triggers the antiviral defense mechanisms. They are implicated in the innate immune system.