The nucleoside from which cordycepin is derived. Introduction: Cordycepin is an antibiotic and antimetabolite produced by the fungus , Cordyceps militaris . It is an analog of purine nucleoside having broad-spectrum biological activity. It inhibits DNA/ RNA synthesis and purine biosynthesis.

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Answer 1

Question

Chapter 26, Problem 1E

(a)

Summary Introduction

To determine: The nucleoside from which cordycepin is derived.

Introduction: Cordycepin is an antibiotic and antimetabolite produced by the fungus, Cordyceps militaris. It is an analog of purine nucleoside having broad-spectrum biological activity. It inhibits DNA/ RNA synthesis and purine biosynthesis.

(a)

Expert Solution

Answer to Problem 1E

Correct answer: Cordycepin is the 3ʹ-deoxy analog of adenosine.

Explanation of Solution

Explanation:

Cordycepin is also known as 3ʹ-deoxyadenosine. Adenosine is a cellular purine nitrogenous base that contributes to various cellular molecular processes. Cordycepin is a derivative of Adenosine. The only difference between them is that cordycepin lacks 3ʹ-hydroxyl group. Thus, cordycepin is referred as 3ʹ-deoxy analog of nucleotide base adenosine.

(b)

Summary Introduction

To explain: The mechanism of action of cordycepin.

Introduction: Cordycepin is an antibiotic and antimetabolite produced by the fungus, Cordyceps militaris. It is an analog of purine nucleoside having broad-spectrum biological activity. It inhibits DNA/ RNA synthesis and purine biosynthesis.

(b)

Expert Solution

Explanation of Solution

Explanation:

Cordycepin is referred as 3ʹ-deoxy analog of nucleotide base adenosine. Adenosine is a cellular purine nitrogenous base that contributes to various cellular molecular processes. During RNA synthesis, certain enzymes are unable to differentiate between adenosine and Cordycepin. This leads to an incorporation of Cordycepin (3ʹ-deoxyadenosine) into the growing RNA chain in the place of normal nitrogenous bases. Since Cordycepin lacks 3ʹ-hydroxyl group, further elongation of RNA chain will be terminated in 5ʹ-3ʹ direction. As a result, premature termination of transcription would occur.

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Students have asked these similar questions

The beta-lactamase hydrolyzes the lactam-ring in penicillin. Describe the mechanism of hydrolysis, insuring to include the involvement of S, D, & K in the reaction sequence. Please help

To map the active site of beta-lactamase, the enzyme was hydrolyzed with trypsin to yield a hexapeptide (P1) with the following amino acids. Glu, Lys, Leu, Phe, Met, and Ser. Treatment of P1 with phenyl isothiocyanate yielded a PTH derivative of phenylalanine and a peptide (P2). Treatment of P1 with cyanogenbromide gave an acidic tetrapeptide (P3) and a dipeptide (P4).Treatment of P2 with 1-fluoro-2,4-dinitrobenzene, followed by complete hydrolysis, yields N-2,4-dinitrophenyl-Glu. P1, P2, and P3 contain the active site serine. Why doesn't D in this hexapeptide not participate in the hydrolysis of the beta-lactam ring even though S, K, and D are involved in the catalyst?

To map the active site of -lactamase, the enzyme was hydrolyzed with trypsin to yield a hexapeptide (P1) with the following amino acids. Glu, Lys, Leu, Phe, Met, and Ser. Treatment of P1 with phenyl isothiocyanate yielded a PTH derivative of phenylalanine and a peptide (P2). Treatment of P1 with cyanogenbromide gave an acidic tetrapeptide (P3) and a dipeptide (P4).Treatment of P2 with 1-fluoro-2,4-dinitrobenzene, followed by complete hydrolysis, yields N-2,4-dinitrophenyl-Glu. P1, P2, and P3 contain the active site serine. Using the experimental results described above derive the primary sequence of the active site hexapeptide. Please help!

Answer 2

Question

Chapter 26, Problem 1E

(a)

Summary Introduction

To determine: The nucleoside from which cordycepin is derived.

Introduction: Cordycepin is an antibiotic and antimetabolite produced by the fungus, Cordyceps militaris. It is an analog of purine nucleoside having broad-spectrum biological activity. It inhibits DNA/ RNA synthesis and purine biosynthesis.

(a)

Expert Solution

Answer to Problem 1E

Correct answer: Cordycepin is the 3ʹ-deoxy analog of adenosine.

Explanation of Solution

Explanation:

Cordycepin is also known as 3ʹ-deoxyadenosine. Adenosine is a cellular purine nitrogenous base that contributes to various cellular molecular processes. Cordycepin is a derivative of Adenosine. The only difference between them is that cordycepin lacks 3ʹ-hydroxyl group. Thus, cordycepin is referred as 3ʹ-deoxy analog of nucleotide base adenosine.

(b)

Summary Introduction

To explain: The mechanism of action of cordycepin.

Introduction: Cordycepin is an antibiotic and antimetabolite produced by the fungus, Cordyceps militaris. It is an analog of purine nucleoside having broad-spectrum biological activity. It inhibits DNA/ RNA synthesis and purine biosynthesis.

(b)

Expert Solution

Explanation of Solution

Explanation:

Cordycepin is referred as 3ʹ-deoxy analog of nucleotide base adenosine. Adenosine is a cellular purine nitrogenous base that contributes to various cellular molecular processes. During RNA synthesis, certain enzymes are unable to differentiate between adenosine and Cordycepin. This leads to an incorporation of Cordycepin (3ʹ-deoxyadenosine) into the growing RNA chain in the place of normal nitrogenous bases. Since Cordycepin lacks 3ʹ-hydroxyl group, further elongation of RNA chain will be terminated in 5ʹ-3ʹ direction. As a result, premature termination of transcription would occur.

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Answer 3

Question

Chapter 26, Problem 1E

(a)

Summary Introduction

To determine: The nucleoside from which cordycepin is derived.

Introduction: Cordycepin is an antibiotic and antimetabolite produced by the fungus, Cordyceps militaris. It is an analog of purine nucleoside having broad-spectrum biological activity. It inhibits DNA/ RNA synthesis and purine biosynthesis.

(a)

Expert Solution

Answer to Problem 1E

Correct answer: Cordycepin is the 3ʹ-deoxy analog of adenosine.

Explanation of Solution

Explanation:

Cordycepin is also known as 3ʹ-deoxyadenosine. Adenosine is a cellular purine nitrogenous base that contributes to various cellular molecular processes. Cordycepin is a derivative of Adenosine. The only difference between them is that cordycepin lacks 3ʹ-hydroxyl group. Thus, cordycepin is referred as 3ʹ-deoxy analog of nucleotide base adenosine.

(b)

Summary Introduction

To explain: The mechanism of action of cordycepin.

Introduction: Cordycepin is an antibiotic and antimetabolite produced by the fungus, Cordyceps militaris. It is an analog of purine nucleoside having broad-spectrum biological activity. It inhibits DNA/ RNA synthesis and purine biosynthesis.

(b)

Expert Solution

Explanation of Solution

Explanation:

Cordycepin is referred as 3ʹ-deoxy analog of nucleotide base adenosine. Adenosine is a cellular purine nitrogenous base that contributes to various cellular molecular processes. During RNA synthesis, certain enzymes are unable to differentiate between adenosine and Cordycepin. This leads to an incorporation of Cordycepin (3ʹ-deoxyadenosine) into the growing RNA chain in the place of normal nitrogenous bases. Since Cordycepin lacks 3ʹ-hydroxyl group, further elongation of RNA chain will be terminated in 5ʹ-3ʹ direction. As a result, premature termination of transcription would occur.

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Answer 4

Question

Chapter 26, Problem 1E

(a)

Summary Introduction

To determine: The nucleoside from which cordycepin is derived.

Introduction: Cordycepin is an antibiotic and antimetabolite produced by the fungus, Cordyceps militaris. It is an analog of purine nucleoside having broad-spectrum biological activity. It inhibits DNA/ RNA synthesis and purine biosynthesis.

(a)

Expert Solution

Answer to Problem 1E

Correct answer: Cordycepin is the 3ʹ-deoxy analog of adenosine.

Explanation of Solution

Explanation:

Cordycepin is also known as 3ʹ-deoxyadenosine. Adenosine is a cellular purine nitrogenous base that contributes to various cellular molecular processes. Cordycepin is a derivative of Adenosine. The only difference between them is that cordycepin lacks 3ʹ-hydroxyl group. Thus, cordycepin is referred as 3ʹ-deoxy analog of nucleotide base adenosine.

(b)

Summary Introduction

To explain: The mechanism of action of cordycepin.

Introduction: Cordycepin is an antibiotic and antimetabolite produced by the fungus, Cordyceps militaris. It is an analog of purine nucleoside having broad-spectrum biological activity. It inhibits DNA/ RNA synthesis and purine biosynthesis.

(b)

Expert Solution

Explanation of Solution

Explanation:

Cordycepin is referred as 3ʹ-deoxy analog of nucleotide base adenosine. Adenosine is a cellular purine nitrogenous base that contributes to various cellular molecular processes. During RNA synthesis, certain enzymes are unable to differentiate between adenosine and Cordycepin. This leads to an incorporation of Cordycepin (3ʹ-deoxyadenosine) into the growing RNA chain in the place of normal nitrogenous bases. Since Cordycepin lacks 3ʹ-hydroxyl group, further elongation of RNA chain will be terminated in 5ʹ-3ʹ direction. As a result, premature termination of transcription would occur.

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Answer 5

Chapter 26, Problem 1E

(a)

Summary Introduction

To determine: The nucleoside from which cordycepin is derived.

Introduction: Cordycepin is an antibiotic and antimetabolite produced by the fungus, Cordyceps militaris. It is an analog of purine nucleoside having broad-spectrum biological activity. It inhibits DNA/ RNA synthesis and purine biosynthesis.

(a)

Expert Solution

Answer to Problem 1E

Correct answer: Cordycepin is the 3ʹ-deoxy analog of adenosine.

Explanation of Solution

Explanation:

Cordycepin is also known as 3ʹ-deoxyadenosine. Adenosine is a cellular purine nitrogenous base that contributes to various cellular molecular processes. Cordycepin is a derivative of Adenosine. The only difference between them is that cordycepin lacks 3ʹ-hydroxyl group. Thus, cordycepin is referred as 3ʹ-deoxy analog of nucleotide base adenosine.

(b)

Summary Introduction

To explain: The mechanism of action of cordycepin.

Introduction: Cordycepin is an antibiotic and antimetabolite produced by the fungus, Cordyceps militaris. It is an analog of purine nucleoside having broad-spectrum biological activity. It inhibits DNA/ RNA synthesis and purine biosynthesis.

(b)

Expert Solution

Explanation of Solution

Explanation:

Cordycepin is referred as 3ʹ-deoxy analog of nucleotide base adenosine. Adenosine is a cellular purine nitrogenous base that contributes to various cellular molecular processes. During RNA synthesis, certain enzymes are unable to differentiate between adenosine and Cordycepin. This leads to an incorporation of Cordycepin (3ʹ-deoxyadenosine) into the growing RNA chain in the place of normal nitrogenous bases. Since Cordycepin lacks 3ʹ-hydroxyl group, further elongation of RNA chain will be terminated in 5ʹ-3ʹ direction. As a result, premature termination of transcription would occur.

Answer 6

Chapter 26, Problem 1E

(a)

Summary Introduction

To determine: The nucleoside from which cordycepin is derived.

Introduction: Cordycepin is an antibiotic and antimetabolite produced by the fungus, Cordyceps militaris. It is an analog of purine nucleoside having broad-spectrum biological activity. It inhibits DNA/ RNA synthesis and purine biosynthesis.

(a)

Expert Solution

Answer to Problem 1E

Correct answer: Cordycepin is the 3ʹ-deoxy analog of adenosine.

Explanation of Solution

Explanation:

Cordycepin is also known as 3ʹ-deoxyadenosine. Adenosine is a cellular purine nitrogenous base that contributes to various cellular molecular processes. Cordycepin is a derivative of Adenosine. The only difference between them is that cordycepin lacks 3ʹ-hydroxyl group. Thus, cordycepin is referred as 3ʹ-deoxy analog of nucleotide base adenosine.

Answer 7

Chapter 26, Problem 1E

(a)

Summary Introduction

To determine: The nucleoside from which cordycepin is derived.

Introduction: Cordycepin is an antibiotic and antimetabolite produced by the fungus, Cordyceps militaris. It is an analog of purine nucleoside having broad-spectrum biological activity. It inhibits DNA/ RNA synthesis and purine biosynthesis.

Answer 8

(a)

Expert Solution

Answer to Problem 1E

Correct answer: Cordycepin is the 3ʹ-deoxy analog of adenosine.

Answer 9

(a)

Expert Solution

Answer 10

(a)

Expert Solution

Answer 11

Expert Solution

Answer 12

Explanation of Solution

Explanation:

Cordycepin is also known as 3ʹ-deoxyadenosine. Adenosine is a cellular purine nitrogenous base that contributes to various cellular molecular processes. Cordycepin is a derivative of Adenosine. The only difference between them is that cordycepin lacks 3ʹ-hydroxyl group. Thus, cordycepin is referred as 3ʹ-deoxy analog of nucleotide base adenosine.

Answer 13

(b)

Summary Introduction

To explain: The mechanism of action of cordycepin.

Introduction: Cordycepin is an antibiotic and antimetabolite produced by the fungus, Cordyceps militaris. It is an analog of purine nucleoside having broad-spectrum biological activity. It inhibits DNA/ RNA synthesis and purine biosynthesis.

(b)

Expert Solution

Explanation of Solution

Explanation:

Cordycepin is referred as 3ʹ-deoxy analog of nucleotide base adenosine. Adenosine is a cellular purine nitrogenous base that contributes to various cellular molecular processes. During RNA synthesis, certain enzymes are unable to differentiate between adenosine and Cordycepin. This leads to an incorporation of Cordycepin (3ʹ-deoxyadenosine) into the growing RNA chain in the place of normal nitrogenous bases. Since Cordycepin lacks 3ʹ-hydroxyl group, further elongation of RNA chain will be terminated in 5ʹ-3ʹ direction. As a result, premature termination of transcription would occur.

Answer 14

(b)

Summary Introduction

To explain: The mechanism of action of cordycepin.

Introduction: Cordycepin is an antibiotic and antimetabolite produced by the fungus, Cordyceps militaris. It is an analog of purine nucleoside having broad-spectrum biological activity. It inhibits DNA/ RNA synthesis and purine biosynthesis.

Answer 15

(b)

Expert Solution

Explanation of Solution

Explanation:

Cordycepin is referred as 3ʹ-deoxy analog of nucleotide base adenosine. Adenosine is a cellular purine nitrogenous base that contributes to various cellular molecular processes. During RNA synthesis, certain enzymes are unable to differentiate between adenosine and Cordycepin. This leads to an incorporation of Cordycepin (3ʹ-deoxyadenosine) into the growing RNA chain in the place of normal nitrogenous bases. Since Cordycepin lacks 3ʹ-hydroxyl group, further elongation of RNA chain will be terminated in 5ʹ-3ʹ direction. As a result, premature termination of transcription would occur.