
(a)
Interpretation:
The structure of quinine in
Concept introduction:
Aliphatic

Answer to Problem 26.33AP
The structure of quinine in
Explanation of Solution
When quinine reacts with
Figure 1
The structure of quinine in
(b)
Interpretation:
The structure of nicotine in
Concept introduction:
Aliphatic amines are more basic than aromatic amines. In aliphatic amines, the nitrogen atom is attached to a methyl group which is electron donating group; therefore, it increases the electron density on nitrogen by

Answer to Problem 26.33AP
The structure of nicotine in
Explanation of Solution
When nicotine reacts with
Figure 2
The structure of nicotine in
(c)
Interpretation:
The structure of tryptamine in
Concept introduction:
Aliphatic amines are more basic than aromatic amines. In aliphatic amines, the nitrogen atom is attached to a methyl group which is electron donating group; therefore, it increases the electron density on nitrogen by

Answer to Problem 26.33AP
The structure of tryptamine in
Explanation of Solution
The aliphatic amine present on the side chain of tryptamine gets protonated in
Figure 3
The structure of tryptamine in
(d)
Interpretation:
The structure of
Concept introduction:
Aliphatic amines are more basic than aromatic amines. In aliphatic amines, the nitrogen atom is attached to a methyl group which is electron donating group; therefore, it increases the electron density on nitrogen by

Answer to Problem 26.33AP
The structure of
Explanation of Solution
In the structure of
Figure 4
The structure of
(e)
Interpretation:
The structure of
Concept introduction:
Aliphatic amines are more basic than aromatic amines. In aliphatic amines, the nitrogen atom is attached to a methyl group which is electron donating group; therefore, it increases the electron density on nitrogen by

Answer to Problem 26.33AP
The structure of
Explanation of Solution
In
Figure 5
The structure of
(f)
Interpretation:
The structure of
Concept introduction:
Aliphatic amines are more basic than aromatic amines. In aliphatic amines, the nitrogen atom is attached to a methyl group which is electron donating group; therefore, it increases the electron density on nitrogen by

Answer to Problem 26.33AP
The structure of
Explanation of Solution
In
The formation of conjugated acid of
Figure 6
The structure of
(g)
Interpretation:
The structure of imitanib in
Concept introduction:
Aliphatic amines are more basic than aromatic amines. In aliphatic amines, the nitrogen atom is attached to a methyl group which is electron donating group; therefore, it increases the electron density on nitrogen by

Answer to Problem 26.33AP
The structure of imitanib in
Explanation of Solution
In imitanib, the aliphatic amine will be protonated than aromatic amine since the basicity of aliphatic amines is more. The aliphatic amine present adjacent to the methyl group will be protonated as it is electron rich due to the
Figure 7
The structure of imitanib in
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Chapter 26 Solutions
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