Chapter 25, Problem 25.45CP

Interpretation Introduction

Interpretation:

The possibility of amino acids be both glucogenic and ketogenic has to be explained.

Concept introduction:

• The carbons atoms of the amino acids are metabolized through two different pathways are called ketogenesis and gluconeogenesis.
• Ketogenesis pathway leads to the formation of ketone bodies, in which carbons are first converted to acetyl-CoA or acetoacetyl-CoA and then to ketone bodies.
• Gluconeogenesis is the process of formation of glucose from non-carbohydrates, in which the pathway leads to the formation pyruvate or the intermediates of citric acid cycle.
• The carbons of Isoleucine leads to the formation Acetyl-CoA and the formation succinyl-CoA