FUND.OF GEN CHEM CHAP 1-13 W/ACCESS
16th Edition
ISBN: 9781323406038
Author: McMurry
Publisher: PEARSON C
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Chapter 25, Problem 25.34AP
Interpretation Introduction
Interpretation:
The step in which aspartate enter the urea cycle has to be identified, compound which eventually leave the cycle has to be determined and
Concept introduction:
The cyclic biological pathway that produces urea for excretion is called urea cycle.
- Step 1: It include carbamoyl phosphate transfers its
- Step 2: Citrulline combines with aspartate to give argininosuccinate synthase
- Step 3: Argininosuccinate is split into arginine and fumarate. The enzyme is argininosuccinase.
- Step 4: The carbon-nitrogen bond of the arginine is hydrolyzed in a reaction catalyzed by arginase to give the cycle product, urea, plus ornithine, ready to repeat step 1
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Students have asked these similar questions
The urea cycle can be summarized through the following reaction:
O
||
H₂N-C-OPO3=
COO-
|
H3N-CHCH₂COO-
O
||
H₂N-C-NH2 + -OOCCH = CHCOO-
1. Write the reactions, using structural formulas that lead to the formation of carbamoyl phosphate and
its subsequent incorporation into the urea cycle. Name the enzymes and how they are activated.
What are the energy consuming steps of the urea cycle and what is the energetic cost of the urea cycle in terms of ATP equivalents? How is this cost partially offset and what is the total net cost of the urea cycle?
The urea cycle can be summarized through the following reaction:
O
||
H2N-C-OPO3
+
COO-
|
H3N-CHCH₂COO
b.
O
||
H2N-C-NH2
1a Write the reactions, using structural formulas that lead to the formation of carbamoyl phosphate and
its subsequent incorporation into the urea cycle. Name the enzymes and how they are activated.
1
+ OOCCH=CHCOO-
Write the rest of the reactions that constitute the urea cycle using structural formulas. Name the
enzymes that catalyze each reaction. Indicate which reactions occur in the mitochondrion and which
occur in the cytoplasm.
Chapter 25 Solutions
FUND.OF GEN CHEM CHAP 1-13 W/ACCESS
Ch. 25.2 - Prob. 25.1PCh. 25.2 - Prob. 25.2KCPCh. 25.3 - Prob. 25.3PCh. 25.3 - Prob. 25.4PCh. 25.3 - Prob. 25.5PCh. 25.3 - Prob. 25.6PCh. 25.4 - Prob. 25.1CIAPCh. 25.4 - Prob. 25.2CIAPCh. 25.4 - Prob. 25.3CIAPCh. 25.4 - Prob. 25.7P
Ch. 25.4 - Prob. 25.8KCPCh. 25.6 - Prob. 25.9PCh. 25.6 - Prob. 25.10KCPCh. 25.6 - What is meant by a conditional amino acid?Ch. 25.6 - Prob. 25.5CIAPCh. 25.6 - Prob. 25.6CIAPCh. 25 - In the diagram shown here, fill in the sources for...Ch. 25 - Prob. 25.12UKCCh. 25 - Prob. 25.13UKCCh. 25 - Prob. 25.14UKCCh. 25 - Prob. 25.15UKCCh. 25 - Prob. 25.16UKCCh. 25 - Prob. 25.17APCh. 25 - Prob. 25.18APCh. 25 - Prob. 25.19APCh. 25 - Prob. 25.20APCh. 25 - Prob. 25.21APCh. 25 - Prob. 25.22APCh. 25 - What is the structure of the -keto acid formed...Ch. 25 - Prob. 25.24APCh. 25 - In general, how does oxidative deamination differ...Ch. 25 - Prob. 25.26APCh. 25 - Prob. 25.27APCh. 25 - Prob. 25.28APCh. 25 - Prob. 25.29APCh. 25 - Prob. 25.30APCh. 25 - Prob. 25.31APCh. 25 - Prob. 25.32APCh. 25 - Prob. 25.33APCh. 25 - Prob. 25.34APCh. 25 - How do essential and nonessential amino acids...Ch. 25 - Prob. 25.36APCh. 25 - Prob. 25.37APCh. 25 - How is tyrosine biosynthesized in the body? What...Ch. 25 - Prob. 25.39APCh. 25 - Prob. 25.40APCh. 25 - Prob. 25.41APCh. 25 - What energy source is used in the formation of...Ch. 25 - Write the equation for the transamination reaction...Ch. 25 - Prob. 25.44CPCh. 25 - Prob. 25.45CPCh. 25 - Prob. 25.46CPCh. 25 - Prob. 25.47CPCh. 25 - Prob. 25.48CPCh. 25 - Prob. 25.49CPCh. 25 - Prob. 25.50CPCh. 25 - Prob. 25.51CPCh. 25 - Prob. 25.52CPCh. 25 - Why might it be a bad idea to take large...Ch. 25 - Prob. 25.54GPCh. 25 - Prob. 25.55GPCh. 25 - Prob. 25.56GP
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Similar questions
- How is the urea cycle linked to the citric acid cycle? Write the net equation of the urea cycle and indicate whether energy is produced or consumed by the cycle. What type of damage occurs if there is a defect in the urea cycle?arrow_forwardHow many ATP equivalents are consumed in the production of one equivalent of urea by the urea cycle?arrow_forwardConsider the following Statements: (1) Citric acid cycle intermediates are often the products from amino acid carbon skeleton degradation. (2) The net effect of transamination is to collect the amino groups from a variety of amino acids into the amino acids glutamate and aspartate. (3) All of the reactions of the urea cycle occur within mitochondria. how many is truearrow_forward
- What form of activated glucose is used in the biosynthesis ofglycogen by bacteria?arrow_forwardGlutamate, produced in the first transamination reaction, reacts with oxaloacetate in the second transamination reaction to form aspartate that can directly enter the urea cycle. In an oxidative deamination reaction, the same glutamate molecule, through the action of glutamate dehydrogenase along with the presence of the coenzyme NAD+, can produce an ammonium ion which can also directly enter the urea cycle. The first statement is incorrect while the second statement is correct The first statement is correct while the second statement is incorrect Both statements are correct Both statements are incorrectarrow_forwardWhich of the following statements regarding the urea cycle is true? (A) Fumarate acts as a connecting link between urea cycle and the CAC.(B) The urea cycle occurs solely in the mitochondria.(C) Citrulline and arginine reacts to form argininosuccinate.(D) Ornithine formed in the last reaction of the urea cycle is excreted from the body along with urea.(E) The purpose of the urea cycle is to produce energy (4 ATP per ammonia that enters) for the liver.arrow_forward
- Which of the following statements about the transamination and deamination steps of amino acid degradation is true? (A) a-ketoglutarate is always formed during a transamination between an amino acid and glutamate. (B) Transamination reactions produce glutamate that is deaminated after entering the urea cycle. (C) Free ammonia is removed from glutamate using glutamate dehydrogenase and NAD+ as an oxidizing agent. (D) The free NH4+ that is removed from glutamate during the deamination reaction is used to form glucose.(E) The carbon backbone that results from transamination enters the mitochondria to be used in the urea cycle.arrow_forwardWhich amino acids in the urea cycle are the links to thecitric acid cycle? Show how these links occurarrow_forwardCarbamoyl-phosphate synthase I is a mitochondrial enzyme which plays an important role in the urea cycle. It represents the committed step in the urea cycle. (i) Explain the reaction of carbamoyl-phosphate synthase I. (ii) Explain the regulation of urea cycle by N-acetylglutamate.arrow_forward
- What is the end product of catabolism of the pyrimidine base thymine? What circumstances cause excess amounts of this end product, and why doesn’t this molecule (unlike uric acid, the end product of purine catabolism) cause a gout-like illness?arrow_forwardWhat enzyme is catalyzed by the reaction of glutamate and NH4+ in order to yield glutamine? Is it uridylyltransferase, adenylyl transferase, glutamate transferase or glutamine synthase?arrow_forwardA newborn is brought into a clinic, and his parents indicate that their baby is lethargic, vomits periodically, and has tremors. It is suspected that the baby might have hyperammonemia. The cause may be due to urea cycle defects, indicating that the high ammonia level is due to an enzymatic block in ammonia metabolism within the urea cycle. What are the enzymes of the urea cycle? Describe their reactions in order to understand the cause of this phenomenon?arrow_forward
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