Biochemistry
9th Edition
ISBN: 9781305961135
Author: Mary K. Campbell, Shawn O. Farrell, Owen M. McDougal
Publisher: Cengage Learning
expand_more
expand_more
format_list_bulleted
Concept explainers
Videos
Question
Chapter 24, Problem 61RE
Interpretation Introduction
Interpretation:
The ways in which some cancers appear to be a lifestyle disease is to be explained.
Concept introduction:
The estrogens are considered the cancer chemical agents that are accountable for cancer commencement.
Insulin is a peptide hormone secreted by the pancreas, while epinephrine (adrenaline) is a neurotransmitter and a hormone that is normally synthesized by the adrenal glands and some neurons.
Expert Solution & Answer
Want to see the full answer?
Check out a sample textbook solution
Students have asked these similar questions
Why don’t we see amino acids with certain properties (e.g., a straight-chain side chain with two carbons, multiple hydroxyl groups, or other unusual structures)?
Please analze the gel electrophoresis column of the VRK1 kinase (MW: 39.71 kDa).
Lane 1: buffer
Lane 2 : Ladder
Lane 3: Lysate
Lane 4: Flowthrough
Lane 5: Wash
Lanes 6-8: E1, E2, E3
Lane 9: Dialyzed VRK1
Lane 10: LDH
Please help
Chapter 24 Solutions
Biochemistry
Ch. 24 - RECALL What are the two primary molecules that...Ch. 24 - Prob. 2RECh. 24 - RECALL Many components of the glycolytic pathway...Ch. 24 - Prob. 4RECh. 24 - Prob. 5RECh. 24 - REFLECT AND APPLY Why is it somewhat misleading to...Ch. 24 - Prob. 7RECh. 24 - Prob. 8RECh. 24 - Prob. 9RECh. 24 - Prob. 11RE
Ch. 24 - RECALL What do we mean when we say that there is...Ch. 24 - Prob. 13RECh. 24 - Prob. 14RECh. 24 - Prob. 15RECh. 24 - Prob. 16RECh. 24 - BIOCHEMICAL CONNECTIONS People who are both...Ch. 24 - Prob. 18RECh. 24 - Prob. 19RECh. 24 - Prob. 20RECh. 24 - REFLECT AND APPLY Immature rats are fed all the...Ch. 24 - Prob. 22RECh. 24 - Prob. 23RECh. 24 - BIOCHEMICAL CONNECTIONS During colonial times,...Ch. 24 - Prob. 25RECh. 24 - Prob. 26RECh. 24 - Prob. 27RECh. 24 - Prob. 28RECh. 24 - Prob. 29RECh. 24 - Prob. 30RECh. 24 - Prob. 31RECh. 24 - Prob. 32RECh. 24 - Prob. 33RECh. 24 - RECALL The hormone thyroxine is given as an oral...Ch. 24 - Prob. 35RECh. 24 - Prob. 36RECh. 24 - Prob. 37RECh. 24 - Prob. 38RECh. 24 - Prob. 39RECh. 24 - Prob. 40RECh. 24 - Prob. 41RECh. 24 - Prob. 42RECh. 24 - Prob. 43RECh. 24 - Prob. 44RECh. 24 - Prob. 45RECh. 24 - Prob. 46RECh. 24 - Prob. 47RECh. 24 - Prob. 48RECh. 24 - Prob. 49RECh. 24 - Prob. 50RECh. 24 - Prob. 51RECh. 24 - Prob. 52RECh. 24 - Prob. 53RECh. 24 - Prob. 54RECh. 24 - Prob. 55RECh. 24 - Prob. 56RECh. 24 - Prob. 57RECh. 24 - Prob. 58RECh. 24 - Prob. 59RECh. 24 - Prob. 60RECh. 24 - Prob. 61RECh. 24 - Prob. 62RECh. 24 - BIOCHEMICAL CONNECTIONS What is the natural...
Knowledge Booster
Learn more about
Need a deep-dive on the concept behind this application? Look no further. Learn more about this topic, biochemistry and related others by exploring similar questions and additional content below.Similar questions
- You have isolated a protein and determined that the native molecular weight of the holoenzyme is 160 kD using size exclusion chromatography. Analysis of this protein using SDS-PAGE revealed 2 bands, one at 100 kD and one at 30 kD. Describe the architecture of the polypeptide component of this enzyme.arrow_forwardIn a cell free preparation of beta-lactamase, penicillin is hydrolyzed in a D2O enriched assay. After one round of catalysis, where would you anticipate finding Deuterium? please help thank youarrow_forwardTo map the active site of -lactamase, the enzyme was hydrolyzed with trypsin to yield a hexapeptide (P1) with the following amino acids. Glu, Lys, Leu, Phe, Met, and Ser. Treatment of P1 with phenyl isothiocyanate yielded a PTH derivative of phenylalanine and a peptide (P2). Treatment of P1 with cyanogenbromide gave an acidic tetrapeptide (P3) and a dipeptide (P4).Treatment of P2 with 1-fluoro-2,4-dinitrobenzene, followed by complete hydrolysis, yields N-2,4-dinitrophenyl-Glu. P1, P2, and P3 contain the active site serine. question: the b-lactamase hydrolyzes the lactam-ring in antibiotics like penicillin. Describe the mechanism, of hydrolysis, insuring to include the involvement of S, D, and K in the reaction sequence. Please help!arrow_forward
- Three of these amino acids participate in the proteolytic hydrolysis of polypeptides. Show the charge-relay network generated by the serine proteases and identify the nucleophilic species that initiates the hydrolysis. please help!arrow_forwardYou have isolated a protein and determined that the native molecular weight of the holoenzyme is 160 kD using size exclusion chromatography. Analysis of this protein using SDS-PAGE revealed 2 bands, one at 100 kD and one at 30 kD. 1. Describe the architecture of the polypeptide component of this enzyme. 2. The enzyme was found to be 0.829% NAD (by weight). What further can be said regarding the architecture? can you please help me with question number 2arrow_forwardTo map the active site of -lactamase, the enzyme was hydrolyzed with trypsin to yield a hexapeptide (P1) with the following amino acids. Glu, Lys, Leu, Phe, Met, and Ser. Treatment of P1 with phenyl isothiocyanate yielded a PTH derivative of phenylalanine and a peptide (P2). Treatment of P1 with cyanogenbromide gave an acidic tetrapeptide (P3) and a dipeptide (P4).Treatment of P2 with 1-fluoro-2,4-dinitrobenzene, followed by complete hydrolysis, yields N-2,4-dinitrophenyl-Glu. P1, P2, and P3 contain the active site serine. Question: although S, K, and D are involved in the catalysis, the E in this hexapeptide does not participate in the hydrolysis of the b-lactam ring. Why is that?arrow_forward
- To map the active site of beta-lactamase, the enzyme was hydrolyzed with trypsin to yield a hexapeptide (P1) with the following amino acids. Glu, Lys, Leu, Phe, Met, and Ser. a) Using the experimental results described below deduce the primary sequence of the active site hexapeptide. Treatment of P1 with phenyl isothiocyanate yielded a PTH derivative of phenylalanine and a peptide (P2). Treatment of P1 with cyanogenbromide gave an acidic tetrapeptide (P3) and a dipeptide (P4).Treatment of P2 with 1-fluoro-2,4-dinitrobenzene, followed by complete hydrolysis, yields N-2,4-dinitrophenyl-Glu. P1, P2, and P3 contain the active site serine. please help!arrow_forwardThe beta-lactamase hydrolyzes the lactam-ring in penicillin. Describe the mechanism of hydrolysis, insuring to include the involvement of S, D, & K in the reaction sequence. Please helparrow_forwardTo map the active site of beta-lactamase, the enzyme was hydrolyzed with trypsin to yield a hexapeptide (P1) with the following amino acids. Glu, Lys, Leu, Phe, Met, and Ser. Treatment of P1 with phenyl isothiocyanate yielded a PTH derivative of phenylalanine and a peptide (P2). Treatment of P1 with cyanogenbromide gave an acidic tetrapeptide (P3) and a dipeptide (P4).Treatment of P2 with 1-fluoro-2,4-dinitrobenzene, followed by complete hydrolysis, yields N-2,4-dinitrophenyl-Glu. P1, P2, and P3 contain the active site serine. Why doesn't D in this hexapeptide not participate in the hydrolysis of the beta-lactam ring even though S, K, and D are involved in the catalyst?arrow_forward
- To map the active site of -lactamase, the enzyme was hydrolyzed with trypsin to yield a hexapeptide (P1) with the following amino acids. Glu, Lys, Leu, Phe, Met, and Ser. Treatment of P1 with phenyl isothiocyanate yielded a PTH derivative of phenylalanine and a peptide (P2). Treatment of P1 with cyanogenbromide gave an acidic tetrapeptide (P3) and a dipeptide (P4).Treatment of P2 with 1-fluoro-2,4-dinitrobenzene, followed by complete hydrolysis, yields N-2,4-dinitrophenyl-Glu. P1, P2, and P3 contain the active site serine. Using the experimental results described above derive the primary sequence of the active site hexapeptide. Please help!arrow_forwardWhich type of enzyme catalyses the following reaction? oxidoreductase, transferase, hydrolase, lyase, isomerase, or ligase.arrow_forward+NH+ CO₂ +P H₂N + ATP H₂N NH₂ +ADParrow_forward
arrow_back_ios
SEE MORE QUESTIONS
arrow_forward_ios
Recommended textbooks for you
BiochemistryBiochemistryISBN:9781305961135Author:Mary K. Campbell, Shawn O. Farrell, Owen M. McDougalPublisher:Cengage Learning
Biochemistry
Biochemistry
ISBN:9781305961135
Author:Mary K. Campbell, Shawn O. Farrell, Owen M. McDougal
Publisher:Cengage Learning
Biomolecules - Protein - Amino acids; Author: Tutorials Point (India) Ltd.;https://www.youtube.com/watch?v=ySNVPDHJ0ek;License: Standard YouTube License, CC-BY