Concept explainers
(a)
Interpretation: The product obtained by the treatment of given compound with LDA, followed by
Concept introduction: Alkylation of
(b)
Interpretation: The product obtained by the treatment of given compound with LDA, followed by
Concept introduction: Alkylation of aldehydes and ketones takes place in the presence of a strong base. The use of appropriate base, solvent and temperature can yield one major product regioselectively.
(c)
Interpretation: The product obtained by the treatment of given compound with LDA, followed by
Concept introduction: Alkylation of aldehydes and ketones takes place in the presence of a strong base. The use of appropriate base, solvent and temperature can yield one major product regioselectively.
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ORGANIC CHEMISTRY
- What enolate is formed when each ketone is treated with LDA in THF solution? What enolate is formed when these same ketones are treated with NaOCH3 in CH3OH solution?arrow_forwardB. Problem 16.74 Provide the missing reagents for each step of this synthesis: a d Br b Br تھ e Br C Br from henzene?arrow_forwardWhat alkyl halide and nucleophile are needed to prepare each compound?arrow_forward
- One step in the synthesis of sitaglipitin (Problem 17.14, a drug used to treat type 2 diabetes) involves reaction of the mixed anhydride A with B to form C. Draw a stepwise mechanism for this reaction.arrow_forwardDevise a synthesis of each compound using 1-bromobutane(CH3CH2CH2CH2Br) as the only organic starting material. You may useany other inorganic reagents.arrow_forwardWhat alkyl halides are formed when attached ether is treated with HBr?arrow_forward
- What is the major E2 elimination product formed from each alkyl halide?arrow_forwardDevise a synthesis of each compound using 1-bromobutane (CH3CH2CH2CH2Br) as the only organic starting material. You may use any other inorganic reagents.arrow_forwardSynthesize each compound from cyclohexanone and organic halides having ≤ 4 C's. You may use any other inorganic reagents.arrow_forward
- Devise a synthesis of each compound from ethanol (CH3CH2OH) as the only source of carbon atoms. You may use any other organic or inorganic reagents you choose.arrow_forwardGive the IUPAC name for each aldehyde.arrow_forwardDraw the product formed from the ring-closing metathesis of each compound. Then, devise a synthesis of each metathesis starting material from benzene, alcohols with four or fewer carbons, and any needed organic or inorganic reagents.arrow_forward