PRESCOTT'S MICROBIOLOGY
PRESCOTT'S MICROBIOLOGY
11th Edition
ISBN: 2818440045677
Author: WILLEY
Publisher: MCG
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Chapter 20.1, Problem 2CC

Why do methanogens use the reductive acetyl-CoA pathway for carbon fixation?

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An organism is fed 14C-labeled acetic acid; the acetic acid is labeled at the 2-carbon(the methyl group carbon). Hint: Go to the Sigma-Aldrich Corporation page on isoprenebiosynthesis and look at the mevalonate pathway. Note that the acetic acid is convertedto acetyl-CoA prior to entering the pathway.Which carbons would contain the radioactive-labeled in the isoprene produced by themevalonate pathway? Circle them, and show how you derived the answer.
What does Succinyl coa By-products in krebs cycle?
Shemin and coworkers used acetatelabeling experiments to conclude that succinyl-CoA is a key intermediate in the biosynthesis of heme. Identify the intermediates in the conversion of acetate into succinyl-CoA.
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