Genetic Analysis: An Integrated Approach (2nd Edition)
2nd Edition
ISBN: 9780321948908
Author: Mark F. Sanders, John L. Bowman
Publisher: PEARSON
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Chapter 20, Problem 11P
In gain-of-function
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Chapter 20 Solutions
Genetic Analysis: An Integrated Approach (2nd Edition)
Ch. 20 - 18.1 Explain why many developmental genes encode...Ch. 20 - Bird beaks develop from an embryonic group of...Ch. 20 - 18.3 How is positional information provided along...Ch. 20 - Early development in Drosophila is atypical in...Ch. 20 - 18.5 Consider the evenskipped regulatory sequences...Ch. 20 - What is the difference between a parasegment and...Ch. 20 - Why do loss-of-function mutations in Hox genes...Ch. 20 - 18.8 Compare and contrast the specification of...Ch. 20 - Prob. 9PCh. 20 - Ablation of the anchor cell in wild type C....
Ch. 20 - 18.11 In gain-of-function and. elegans mutants,...Ch. 20 - Prob. 12PCh. 20 - Prob. 13PCh. 20 - 18.14 Given that maternal Bicoid activates the...Ch. 20 - What phenotypes do you expect in flies homozygous...Ch. 20 - The pair rule gene fushitarazu is expressed in...Ch. 20 - 18.17 In contrast to Drosophila, some insects...Ch. 20 - Prob. 18PCh. 20 - 18.19 You are traveling in the Netherlands and...Ch. 20 - 19.20 A powerful approach to identifying genes of...Ch. 20 - Prob. 21PCh. 20 - The Hoxd 913 genes are thought to specify digit...Ch. 20 - Three-spined stickleback fish live in lakes formed...Ch. 20 - In C. elegans there are two sexes: hermaphrodite...Ch. 20 - The flowering jungle plant Lacandoniaschismatica,...Ch. 20 - 18.24 Homeotic genes are thought to regulate each...Ch. 20 - Prob. 27PCh. 20 - Basidiomycota is a monophyletic group of fungi...Ch. 20 - In Drosophila, recessive mutations in the...
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- EXTRANUCLEAR INHERITANCE In drosophila, a recessive mutation (m-) of a maternal effect gene (MEG) results in an abnormal phenotype wherein homozygous (m-m-) females produce eggs that cannot support embryonic development. Homozygous (m-m-) males, however, can still produce viable sperm. Using m+ to denote a normal gene, determine the genotypes and phenotypes of the F1s produced by a cross between a heterozygous female and a recessive male. From the offspring, backcross the recessive female with the paternal strain. What are the genotypes and phenotypes of the F2s? with COMPLETE cross for both cases.arrow_forwardDescribe the molecular process of X-chromosome inactivation.This description should include the three phases of inactivationand the role of the Xic. Explain what happens to the X chromosomes during embryogenesis, in adult somatic cells, and duringoogenesis.arrow_forwardThe BCRA-1 allele is associated with very high risk of breast and ovarian cancers. Is this allele consistent with the mutation accumulation theory or the antagonistic pleiotropy theory of senescence? Why? A couple of sentences answer is fine.arrow_forward
- Equalizing the Expression of X Chromosome Genes in Males and Females Individuals with an XXY genotype are sterile males. If one X is inactivated early in embryogenesis, the genotype of the individual effectively becomes XY. Why will this individual not develop as a normal male?arrow_forwardThe gene controlling ABO blood type and the gene underlying nail-patella syndrome are said to show linkage. What does that mean in terms of their relative locations in the genome? What does it mean in terms of how the two traits are inherited with respect to each other?arrow_forwardWhen the His− Salmonella strain used in the Ames testis exposed to substance X, no His+ revertants are seen.If, however, rat liver supernatant is added to the cellsalong with substance X, revertants do occur. Is substanceX a potential carcinogen for human cells? Explainarrow_forward
- The oncogenic protein BETA promotes entry into the S phase of the cell cycle. Phosphorylation of BETA at the amino acid Tyr98 causes BETA to be degraded by the proteasome, thus limiting its abundance. A mutation in the codon encoding Tyr98 changes this residue to Cys, which cannot be phosphorylated. What is the best description of this mutant allele?a) antimorphb) hypermorphc) hypomorphd) amorphe) neomorpharrow_forwardPolarity of oocyte of DrosophilaWhat is the difference between the anterior and posterior determinant for the oocyte?arrow_forwardSuppose a researcher has three different Drosophila strains that have mutations in the bicoid gene called bicoid-A, bicoid-B, and bicoid-C; the wild type is designated bicoid +. To study these mutations, phenotypically normal female flies that are homozygous for the given bicoid mutation were obtained, and their oocytes were analyzed using a Northern blot to determine the size and/or amount of the bicoid mRNA and in situ hybridization to determine the bicoid mRNA location within the oocyte. A wild-type strain was also analyzed as a control. In both cases, the probe was complementary to the bicoid mRNA and the results are shown below. (Anterior is on the left; posterior is on the right.) Northern blot 1 2 - 3 4 In situ hybridization Wild type Lane 1. Wild type (bicoid*) Lane 2. bicoid-A Lane 3. bicoid-B Lane 4. bicoid-C bicoid-B bicoid-A bicoid-C Which mutation is likely to cause the embryo to develop two "anterior" ends? bicoid-B Obicoid-A bicoid-Carrow_forward
- In humans, dosage compensation is accomplished by: inactivating one X chromosome in female somatic cells inactivating one homolog from each homologous pair of chromosomes in female somatic cells inactivating the Y chromosome in male somatic cells increasing gene expression from the X chromosome in male somatic cellarrow_forwardAPOE gene has been found to be a major contributor to sporadic Alzheimer's disease (AD), by acting as an age-of-onset modifier for the common relatively late-onset forms of the disease. Among four alleles causing early onset of AD, the epsilon4 allele (APOE4) disrupts this function. If you generate transgenic monkeys in which the normal allele of APOE gene is knocked out, what phenotype will you expect for those knockout monkeys? A. The APE mRNA expression will be completely suppressed. B. They slow down the development of AD. C. They develop AD early. D. They don't show any AD symptom.arrow_forwardX chromosome inactivation in a diploid XX female is not completely inactivated, explain?arrow_forward
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