Fundamentals of General, Organic, and Biological Chemistry (8th Edition)
8th Edition
ISBN: 9780134015187
Author: John E. McMurry, David S. Ballantine, Carl A. Hoeger, Virginia E. Peterson
Publisher: PEARSON
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Chapter 2, Problem 2.36AP
Interpretation Introduction
Interpretation:
Mass in grams of the oxygen atom should be identified.
One atomic mass unit is given below
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The beta-lactamase hydrolyzes the lactam-ring in penicillin. Describe the mechanism
of hydrolysis, insuring to include the involvement of S, D, & K in the reaction sequence. Please help
To map the active site of beta-lactamase, the enzyme was hydrolyzed with trypsin to yield a hexapeptide (P1) with the following amino acids. Glu, Lys, Leu, Phe, Met, and Ser. Treatment of P1 with phenyl isothiocyanate yielded a PTH derivative of phenylalanine and a peptide (P2). Treatment of P1 with cyanogenbromide gave an acidic tetrapeptide (P3) and a dipeptide (P4).Treatment of P2 with 1-fluoro-2,4-dinitrobenzene, followed by complete hydrolysis, yields N-2,4-dinitrophenyl-Glu. P1, P2, and P3 contain the active site serine.
Why doesn't D in this hexapeptide not participate in the hydrolysis of the beta-lactam ring even though S, K, and D are involved in the catalyst?
To map the active site of -lactamase, the enzyme was hydrolyzed with trypsin to yield a hexapeptide (P1) with the following amino acids. Glu, Lys, Leu, Phe, Met, and Ser. Treatment of P1 with phenyl isothiocyanate yielded a PTH derivative of phenylalanine and a peptide (P2). Treatment of P1 with cyanogenbromide gave an acidic tetrapeptide (P3) and a dipeptide (P4).Treatment of P2 with 1-fluoro-2,4-dinitrobenzene, followed by complete hydrolysis, yields N-2,4-dinitrophenyl-Glu. P1, P2, and P3 contain the active site serine.
Using the experimental results described above derive the primary sequence of the active site hexapeptide. Please help!
Chapter 2 Solutions
Fundamentals of General, Organic, and Biological Chemistry (8th Edition)
Ch. 2.1 - Prob. 2.1CIAPCh. 2.1 - For the Kanji character in the lower portion of...Ch. 2.2 - Use the list inside the front cover to identify...Ch. 2.3 - Prob. 2.2PCh. 2.3 - Prob. 2.3PCh. 2.3 - Prob. 2.4PCh. 2.4 - Prob. 2.5PCh. 2.4 - Prob. 2.6PCh. 2.4 - Prob. 2.7PCh. 2.4 - Prob. 2.8P
Ch. 2.4 - Prob. 2.9PCh. 2.5 - Prob. 2.10PCh. 2.5 - Prob. 2.11PCh. 2.5 - Prob. 2.12PCh. 2.5 - Prob. 2.13KCPCh. 2.5 - Prob. 2.3CIAPCh. 2.5 - Prob. 2.4CIAPCh. 2.6 - Prob. 2.14PCh. 2.7 - Prob. 2.15PCh. 2.7 - Write electron configurations for the following...Ch. 2.7 - Prob. 2.17PCh. 2.7 - Identify the atom with the following...Ch. 2.8 - Prob. 2.19PCh. 2.8 - Prob. 2.20PCh. 2.8 - Prob. 2.21PCh. 2.8 - Prob. 2.22KCPCh. 2.9 - Prob. 2.23PCh. 2.9 - Write electron-dot symbols for radon, lead, xenon,...Ch. 2.9 - Prob. 2.25PCh. 2.9 - Prob. 2.5CIAPCh. 2.9 - Prob. 2.6CIAPCh. 2 - Where on the following outline of a periodic table...Ch. 2 - Is the element marked in red on the following...Ch. 2 - Prob. 2.28UKCCh. 2 - What atom has the following orbital-filling...Ch. 2 - Use the following orbital-filling diagram to show...Ch. 2 - What four fundamental assumptions about atoms and...Ch. 2 - How do atoms of different elements differ?Ch. 2 - Prob. 2.33APCh. 2 - Prob. 2.34APCh. 2 - Prob. 2.35APCh. 2 - Prob. 2.36APCh. 2 - How many O atoms of mass 15.99 amu are in 15.99 g...Ch. 2 - Prob. 2.38APCh. 2 - What are the names of the three subatomic...Ch. 2 - Prob. 2.40APCh. 2 - Prob. 2.41APCh. 2 - Prob. 2.42APCh. 2 - Which of the following symbols represent isotopes...Ch. 2 - Prob. 2.44APCh. 2 - Prob. 2.45APCh. 2 - Prob. 2.46APCh. 2 - One of the most widely used isotopes in medical...Ch. 2 - Prob. 2.48APCh. 2 - Prob. 2.49APCh. 2 - Prob. 2.50APCh. 2 - Prob. 2.51APCh. 2 - Prob. 2.52APCh. 2 - Prob. 2.53APCh. 2 - Prob. 2.54APCh. 2 - Prob. 2.55APCh. 2 - For (a) rubidium (b) tungsten, (c) germanium, and...Ch. 2 - For (a) calcium, (b) palladium, (c) carbon, and...Ch. 2 - Prob. 2.58APCh. 2 - Prob. 2.59APCh. 2 - Prob. 2.60APCh. 2 - Prob. 2.61APCh. 2 - Prob. 2.62APCh. 2 - Prob. 2.63APCh. 2 - Prob. 2.64APCh. 2 - Prob. 2.65APCh. 2 - Prob. 2.66APCh. 2 - Prob. 2.67APCh. 2 - Prob. 2.68APCh. 2 - Prob. 2.69APCh. 2 - Prob. 2.70APCh. 2 - Prob. 2.71APCh. 2 - Determine the number of unpaired electrons for...Ch. 2 - Without looking back in the text, write the...Ch. 2 - Prob. 2.74APCh. 2 - Prob. 2.75APCh. 2 - Prob. 2.76APCh. 2 - Prob. 2.77APCh. 2 - Prob. 2.78APCh. 2 - Using n for the number of the valence shell and...Ch. 2 - What elements in addition to helium make up the...Ch. 2 - Prob. 2.81CPCh. 2 - What is the atomic number of the yet-undiscovered...Ch. 2 - Give the number of electrons in each shell for...Ch. 2 - Identify the highest-energy occupied subshell in...Ch. 2 - Prob. 2.85CPCh. 2 - Prob. 2.86CPCh. 2 - Germanium, atomic number 32, is used in building...Ch. 2 - Prob. 2.88CPCh. 2 - Prob. 2.89CPCh. 2 - What is wrong with the following electron...Ch. 2 - Prob. 2.91CPCh. 2 - Prob. 2.92CPCh. 2 - Prob. 2.93CPCh. 2 - Prob. 2.94CPCh. 2 - Prob. 2.95GPCh. 2 - Prob. 2.96GPCh. 2 - Prob. 2.97GPCh. 2 - Look again at the trends illustrated in Figures...
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