Genetic Analysis: An Integrated Approach (2nd Edition)
2nd Edition
ISBN: 9780321948908
Author: Mark F. Sanders, John L. Bowman
Publisher: PEARSON
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Chapter 19, Problem 22P
What is the most likely mode of inheritance for the trait depicted in the following human pedigree?
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a) Which of the four modes of inheritance are consistent with the disease shown in this human pedigrees below? (List the compatible mode or modes) Give an answer for a, b and c
b) If the parents in pedigree c have 2 other children, what is the probability that they will carry the disease?
Below is a pedigree of a human genetic disease in which solid color indicates affected individuals. Assume that the disease is caused by a gene that can have the alleles A or a.
a) Based on this pedigree, what is the most likely mode of inheritance?
b) What is/are the possible genotype/s of person 1?
c) What is/are the possible genotype (s) of person 4 ?
Explain your answers.
An unaffected woman for a human disorder marries and unaffected man and they have
children. This results in 3 affected sons, and one unaffected daughter, which ends up having
children later on with an unaffected man and has 2 affected sons.
A) Draw a simple pedigree diagram for this family, including a legend.
B) What is the likely mode of inheritance of this trait: Please explain
C) Provide the genotypes of the original mother and the daughter. Use a capital letter for the
dominant allele and lowercase letter for the recessive allele.
D) If one of the affected sons from the original marriage marries a 2nd cousin that is a carrier of
this trait and has children, what is the probability that they will have 3 affected sons?
Chapter 19 Solutions
Genetic Analysis: An Integrated Approach (2nd Edition)
Ch. 19 - 17.1 Reciprocal crosses of experimental animals or...Ch. 19 - 17.2 How are some of the characteristics of the...Ch. 19 - 17.3 The human mitochondrial genome encodes...Ch. 19 - What is the evidence that transfer of DNA from the...Ch. 19 - Draw a graph depicting the relative amounts of...Ch. 19 - Prob. 6PCh. 19 - 17.7 What is the evidence that the ancient...Ch. 19 - 17.8 Outline the steps required for a gene...Ch. 19 - 17.9 Consider the phylogenetic tree presented in...Ch. 19 - Most large protein complexes in mitochondria and...
Ch. 19 - What insights have analyses of human mitochondrial...Ch. 19 - You are a genetic counselor, and several members...Ch. 19 - A mutation in Arabidopsis immutans results in the...Ch. 19 - What type or types of inheritance are consistent...Ch. 19 - You have isolated (1) a streptomycin-resistant...Ch. 19 - You have isolated two petite mutants, pet1 and...Ch. 19 - 17.15 Consider this human pedigree for a vision...Ch. 19 - A 50- year - old man has been diagnosed with MELAS...Ch. 19 - 17.17 The first person in a family to exhibit...Ch. 19 - Prob. 20PCh. 19 - Prob. 21PCh. 19 - 17.19 What is the most likely mode of inheritance...Ch. 19 - 17.20 In , the Russian Tsar Nicholaswas deposed,...Ch. 19 - 17.21 The dodo bird (Raphus cucullatus) lived on...Ch. 19 - Cytoplasmic male sterility (CMS) in plants has...Ch. 19 - 17.23 Wolves and coyotes can interbreed in...Ch. 19 - Prob. 27PCh. 19 - Prob. 28P
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- The following family pedigree shows individuals afflicted with a metabolic disease. Suppose the male (b) and the female (c) have 2 girls and 2 boys, indicate directly on the pedigree the symbols for these children that would be most consistent with the mode of inheritance observations in the pedigree? II II a b d e IVarrow_forwardEctrodactyly is a rare condition in which the fingers are absent and the hand is split. This condition is usually inherited as an autosomal dominant trait. Ademar Freire-Maia reported the appearance of ectrodactyly in a family in São Paulo, Brazil, whose pedigree is shown here. Is this pedigree consistent with autosomal dominant inheritance? If not, what mode of inheritance is most likely? Explain your reasoning.arrow_forwardEctrodactyly is a rare condition in which the fingers are absent and the hand is split. This condition is usually inherited as an autosomal dominant trait. Ademar Freire-Maia reported the appearance of ectrodactyly in a family in São Paulo, Brazil, whose pedigree is shown here. Is this pedigree consistent with autosomal dominant inheritance? If not, what mode of inheritance is most likely? Explain your reasoning.arrow_forward
- Shown below is a pedigree for Phenylketonuria (PKU), an autosomal recessive metabolic disorder. The characteristic feature of PKU is severe mental retardation A) What is the probability that individual II-1 is heterozygous for this gene? B) What is the probability that individual III-4 is heterozygous for this gene? C) If individuals III-3 and III-4 were to marry, what is the probability that their child would express PKU?arrow_forwardConsider the following pedigree. Solid symbols represent individuals affected by the trait. Assume complete penetrance and non-variable expressivity. II 3 4 III 1 2 3 5 6 a) what is the mode of inheritance of this trait? b) Does the ratio of affected to unaffected offspring in generation III-1 to 1II-4 match the expected ratio for this mode of inheritance? Explain your answer in terms of the expected ratio versus the ratio observed. Give a reason for your answer. No mark is assigned for yes or no)arrow_forwardAlbinism in humans is inherited as a simple recessive trait. For the following families, determine the genotypes of the parents and offspring. (When two alternative genotypes are possible, list both.) (a) Two normal parents have five children, four normal and one albino. (b) A normal male and an albino female have six children, all normal. (c) A normal male and an albino female have six children, three normal and three albino. (d) Construct a pedigree of the families in (b) and (c). Assume that one of the normal children in (b) and one of the albino children in (c) become the parents of eight children. Add these children to the pedigree, predicting their phenotypes (normal or albino).arrow_forward
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