Concepts of Genetics (12th Edition)
12th Edition
ISBN: 9780134604718
Author: William S. Klug, Michael R. Cummings, Charlotte A. Spencer, Michael A. Palladino, Darrell Killian
Publisher: PEARSON
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Chapter 19, Problem 19PDQ
A developmental disorder in humans called spina bifida is a neural tube defect linked to a maternal diet low in folate during pregnancy.
- (a) What does this suggest about the cause of spina bifida?
- (b) Does this exclude genetic mutations as a cause of this condition?
- (c) Should researchers be looking for mutant alleles of genes that control formation and differentiation of the neural tube?
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The somatic stem cells are derived from source such as_________.a) Bone marrow, embryos, amniotic fluid and umbilical cord b) Embryos, bone, knee, foetus c) Bone marrow, fluid, umbilical cord, joint cells d) Embryo, foetus, umbilical cord, fluid.
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Chapter 19 Solutions
Concepts of Genetics (12th Edition)
Ch. 19 - Although histone modifications can activate or...Ch. 19 - Prob. 2NSTCh. 19 - Prob. 1CSCh. 19 - Prob. 2CSCh. 19 - A couple well informed about the epigenetic...Ch. 19 - Prob. 1PDQCh. 19 - Prob. 2PDQCh. 19 - Prob. 3PDQCh. 19 - Prob. 4PDQCh. 19 - Prob. 5PDQ
Ch. 19 - Prob. 6PDQCh. 19 - Prob. 7PDQCh. 19 - Prob. 8PDQCh. 19 - Prob. 9PDQCh. 19 - Prob. 10PDQCh. 19 - What are the functions of IncRNAs in epigenetic...Ch. 19 - Prob. 12PDQCh. 19 - What are the differences and similarities among...Ch. 19 - Prob. 14PDQCh. 19 - Prob. 15PDQCh. 19 - Should fertility clinics be required by law to...Ch. 19 - Prob. 17PDQCh. 19 - Prob. 18PDQCh. 19 - A developmental disorder in humans called spina...Ch. 19 - Prob. 20PDQCh. 19 - PraderWilli syndrome (PWS) is a genetic disorder...Ch. 19 - Prob. 22ESPCh. 19 - Prob. 23ESPCh. 19 - Methylation of H3K9 by itself silences genes, but...
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- From a genetics point of view in simplified terms Breakdown Muscular Dystrophy 1.) Explain the specific genes involved 2.) Explain becker vs. duchenne dystrophies 3.) Explain treatmentsarrow_forward64. Embryonic stem (ES) cells differ from somatic stem cells in that ... a) ES cells can only be derived from early embryos, whereas somatic stem cells are present in adult tissues. b) ES cells retain the ability to renew themselves, whereas somatic stem cells do not. c) ES cells are pluripotent and can differentiate into any cell type in the developing embryo, whereas somatic stem cells are considered multipotent in that they produce a more limited number of differentiated cell types. d) a and c e) a, b and carrow_forwardWhich of the examples of genetic testing below are prognostic tests? Which are diagnostic? (a) Individual sequencing (personal genomics) identifies a mutation associated with Alzheimer’s disease. (b) ASO testing determines that an individual is a carrier for the mutant b@globin allele (bS) found in sickle-cell anemia. (c) DNA sequencing of a breast tumor reveals mutations in the BRCA1 gene. (d) Genetic testing in a healthy teenager identifies an SNP correlated with autism. (e) An adult diagnosed with Asperger syndrome (AS) has a genetic test that reveals a SNP in the GABRB3 gene that is significantly more common in people with AS than the general population.arrow_forward
- What are some of the ethical issues that arise from using embryonic stem cells?(b) To avoid these issues, scientists use IPSCs. What are the pros and cons to using iPSCs inrelation to embryonic stem cells?arrow_forwardWhat specific molecular factors determine the differentiation of embryonic stem cells into different cell types during development?arrow_forward16)Tamoxifen acts as a ............. pharmaceutical agent: a)Estrogen receptor–blocking b)hormone therapy drug, is used to treat breast cancers c)Non–cell cycle active d)All choices e) both a and barrow_forward
- The phenotype of a heterozygous mouse (Aa) is agouti. The agouti banding pattern is due to altered expression of the agouti gene. Which of the following statement is false? a) Expression of the agouti gene inhibits the production of eumelanin. b) Evidence suggests that the agouti gene is only expressed in tissues associated with fur production. c) Epigenetic markers silence the agouti gene resulting in dark pigmentation at the tip and root of the hair. d) All of the abovearrow_forwardMany oncogenes result from mutations that cause excessive expression of a protein in cells where it is normally not expressed or is expressed at inappropriate times during development. This type of mutation can be described as ________. A) amorphic B) hypomorphic C)hypermorphic D) neomorphic E) dominant negativearrow_forward11) Postpartum estrus (PPE) is the period of receptivity immediately following parturition (giving birth). Select all that apply a) It occurs because the drop in progesterone levels resulting from the regression of the CL release DA from inhibition. b) A mouse can be pregnant and nursing a litter at the same time. If she is, the P4 coming from the CL of her pregnancy will prevent her from cycling from PPE to parturition. c) If a mouse mates with a sterile male during PPE, the resulting CL will still be maintained by the PRL released in response to suckling so she will not cycle from PPE to parturition. d) A mouse that breeds during PPE and continues to nurse the first litter may have a longer than normal gestation due to embryonic diapause. e) A mouse that breeds during PPE and continues to nurse the first litter may have a smaller than normal litter due to embryonic diapause.arrow_forward
- The BMP-Nodal gradient so vital to amphibian and fish development may be critically important in other vertebrates (including humans) as well. Moreover, can any field of pluripotent cells (such as human embryonic stem cells)respond to gradients of BMP and Nodal signals?arrow_forwardWhich of the following statements about cancer is false? (a) oncogenes arise from mutations in proto-oncogenes (b) tumor suppressor genes normally interact with growthinhibiting factors to block cell division (c) more than 120cancer-driving genes have been discovered (d) oncogenes were first discovered in mouse models for cancer (e) the development of cancer is usually a multistep process involving both oncogenes and mutated tumor suppressor genesarrow_forwardWhich of the following effectively describes the situation of someone with an inherited predisposition to cancer such as familial adenomatous polyposis or BRCA-associated familial breast cancer? Choose all that apply a) If they get malignant cancer, somatic mutations will not have been a factor b) Their cancer will most likely arise in their germ cells, not their somatic cells c) None of the answers effectively describes the situation d) Every cell of their body contains a gain-of-function allele of an oncogene e) Most cells in their body contain multiple cancer-causing mutations f) Every cell of their body contains a defective, loss-of-function allele of a tumor suppressor genearrow_forward
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