Genetics: From Genes to Genomes, 5th edition
Genetics: From Genes to Genomes, 5th edition
5th Edition
ISBN: 9780073525310
Author: Leland H. Hartwell, Michael L. Goldberg, Janice A. Fischer, Leroy Hood, Charles F. Aquadro
Publisher: McGraw-Hill Education
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Chapter 18, Problem 30P

The Drosophila even-skipped (eve) gene has four different enhancers that control its transcription in a pattern of seven stripes. (One of them—the stripe 2 enhancer—is shown in Fig. 18.23c on p. 616.)

a. Why is the stripe 2 enhancer active only in cells corresponding to stripe 2?
b. The other three enhancers each work in the cells corresponding to two different (nonadjacent) stripes. How is this possible?
c. Secondary pair-rule genes like ftz have only one enhancer that is active in all seven stripes. How is this possible? Describe an experiment that would have led scientists to this conclusion.
d. Would you expect the segment polarity gene engrailed to have one enhancers or 14 enhancers, one active in each stripe?
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