Organic Chemistry
Organic Chemistry
11th Edition
ISBN: 9781118133576
Author: T. W. Graham Solomons, Craig Fryhle
Publisher: Wiley, John & Sons, Incorporated
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Chapter 18, Problem 27P
Interpretation Introduction

Interpretation:

The reaction sequence of the given compounds along with the reagents are to be determined.

Concept Introduction:

Electrophiles are electron deficient species which has positive or partially positive charge. Lewis acids are electrophiles which accept electron pair.

Nucleophiles are electron rich species which has negative or partially negative charge. Lewis bases are nucleophiles which donate electron pair.

βdicarbonyl > compound can be converted into enolate ions in the presence sodium ethoxide.

Alkylation of the βdicarbonyl > compound is an SN2 > reaction.

LDA stands for lithium disopyramide. It is a strong base.

In SN2 reaction, one bond is broken and one bond is formed in one step.

Sn2 is a kind of nucleophilic substitution reaction mechanism. Since two reacting species are involved in the slow (rate-determing) step, this leads to the term substitution nucleophilic (bi-molecular) or SN2 >.

In SN2 reaction, the nucleophile attacks on the less sterically hindered carbon. SN2 reaction gives inversion. The reaction takes place in polar aprotic solvents.

When halogen substitution reaction takes place in the presence of acid, it is called acid catalyzed halogenation reaction.

Decarboxylation is the chemical reaction which transfers COOH > with the liberation of carbon dioxide. Decarboxylation of a carboxylic acid takes place in the presence of heat.

Alkylation of ketones takes place with the help of lithium enolates.

Sodium hydride is used to generate the enolate ions.

The α hydrogens can undergo halogen substitution reaction in the presence of acid and base.

When halogen substitution reaction takes places in the presence of acid, it is called acid catalyzed halogenation reaction.

When halogen substitution reaction takes places in the presence of a base, it is called base prompted halogenation reaction.

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Students have asked these similar questions
Propose a reasonable synthesis for each of the following compounds from the indicated starting materials and any other reagents.
(a) (b) (c) Suggest a synthesis of the following alkene (A) using a Wittig reaction strategy. Draw the starting material(s), key reagent and a full reaction mechanism including an explanation of the observed geometry. Which of the following (B) and (C) will favour the enol form? Briefly explain your reasoning. Predict the product(s) and provide a mechanism for each of the following transformations: (i) (ii) OMe OMe Base OEt NaOEt
Propose suitable reagents to accomplish the following transformations.

Chapter 18 Solutions

Organic Chemistry

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